EC Explorer
[browse EC tree] - [search]
EC 1.5.3.5 Details
show Brenda entryEC number
1.5.3.5
Accepted name
(S)-6-hydroxynicotine oxidase
Reaction
(S)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O2 (overall reaction);;(1a) (S)-6-hydroxynicotine + O2 = 5-(N-methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O2;;(1b) 5-(N-methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol + H2O = 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one (spontaneous)
Other name(s)
L-6-hydroxynicotine oxidase,
6-hydroxy-L-nicotine oxidase,
6-hydroxy-L-nicotine:oxygen oxidoreductase,
nctB (gene name)
Systematic name
(S)-6-hydroxynicotine:oxygen oxidoreductase
CAS registry number
37256-29-4
Comment
A flavoprotein (FAD). The enzyme, which participates in nicotine degradation, is specific for the (S) isomer of 6-hydroxynicotine. The bacterium Arthrobacter nicotinovorans, in which this enzyme was originally discovered, has a different enzyme that catalyses a similar reaction with the less common (R)-isomer (cf. EC 1.5.3.6, (R)-6-hydroxynicotine oxidase).
History
created 1972, modified 2015
back to topEC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.5.3.3 created 1961, deleted 1972 1.5.3.8 created 1989, deleted 1992 1.5.3.9 created 1989, modified 1999, deleted 2002 1.97.1.5 created 2000 deleted 2001 1.97.1.6 created 2000 deleted 2001 1.97.1.7 created 2000, deleted 2001
