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EC 1.6.3.5 Details
show Brenda entryEC number
1.6.3.5
Accepted name
renalase
Reaction
(1) 1,2-dihydro-β-NAD(P) + H+ + O2 = β-NAD(P)+ + H2O2;;(2) 1,6-dihydro-β-NAD(P) + H+ + O2 = β-NAD(P)+ + H2O2
Other name(s)
αNAD(P)H oxidase/anomerase (incorrect),
NAD(P)H:oxygen oxidoreductase (H2O2-forming, epimerising) (incorrect)
Systematic name
dihydro-NAD(P):oxygen oxidoreductase (H2O2-forming)
Comment
Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of β-NAD(P)H back to β-NAD(P)+. These isomeric forms, generated by nonspecific reduction of β-NAD(P)+ or by tautomerization of β-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.
History
created 2014, modified 2015
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.6.1 created 1961, deleted 2002 1.6.6.2 created 1961, deleted 2002 1.6.6.3 created 1961, deleted 2002 1.6.6.4 created 1961, deleted 2002 1.6.6.5 created 1961, deleted 1964 1.6.6.6 created 1961, deleted 2002 1.6.6.7 created 1961, deleted 2002 1.6.6.8 created 1965, deleted 2002 1.6.6.10 created 1972, deleted 2002 1.6.6.11 created 1972, deleted 2002 1.6.6.12 created 1989, deleted 2002 1.6.6.13 created 1989, deleted 2002
