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EC 1.6.3.5 Details

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EC number

1.6.3.5

Accepted name

renalase

Reaction

(1) 1,2-dihydro-β-NAD(P) + H⁺ + O₂ = β-NAD(P)⁺ + H₂O₂;;(2) 1,6-dihydro-β-NAD(P) + H⁺ + O₂ = β-NAD(P)⁺ + H₂O₂

Other name(s)

αNAD(P)H oxidase/anomerase (incorrect), NAD(P)H:oxygen oxidoreductase (H₂O₂-forming, epimerising) (incorrect)

Systematic name

dihydro-NAD(P):oxygen oxidoreductase (H₂O₂-forming)

Comment

Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of β-NAD(P)H back to β-NAD(P)⁺. These isomeric forms, generated by nonspecific reduction of β-NAD(P)⁺ or by tautomerization of β-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.

History

created 2014, modified 2015

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.2 With a heme protein as acceptor

1.6.3 With oxygen as acceptor

1.6.3.1 NAD(P)H oxidase (H₂O₂-forming)

1.6.3.2 NAD(P)H oxidase (H₂O-forming)

1.6.3.3 NADH oxidase (H₂O₂-forming)

1.6.3.4 NADH oxidase (H₂O-forming)

1.6.3.5 renalase

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.11.1 Peroxidases

1.11.2 Peroxygenases

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.18.1 With NAD⁺ or NADP⁺ as acceptor

1.18.2 With dinitrogen as acceptor (deleted sub-subclass)

1.18.3 With H⁺ as acceptor (deleted sub-subclass)

1.18.6 With dinitrogen as acceptor

1.18.96 With other, known, acceptors (deleted sub-subclass)

1.18.99 With H⁺ as acceptor (deleted sub-subclass)

1.18.99.1 created 1961 as EC 1.98.1.1, transferred 1965 to EC 1.12.1.1, transferred 1972 to EC 1.12.7.1, transferred 1978 to EC 1.18.3.1, transferred 1984 to EC 1.18.99.1, deleted 2002

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)