EC Explorer

[browse EC tree] - [search]

EC 3.5.4.43 Details

show Brenda entry

EC number

3.5.4.43

Accepted name

hydroxydechloroatrazine ethylaminohydrolase

Reaction

hydroxyatrazine + H₂O = N-isopropylammelide + ethylamine

Other name(s)

atzB (gene name), 2,4-dihydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase

Systematic name

hydroxyatrazine ethylaminohydrolase

Comment

Contains Zn²⁺. This bacterial enzyme is involved in degradation of the herbicide atrazine. The enzyme has a broad substrate range, and requires a monohydroxylated s-triazine ring with a minimum of one primary or secondary amine substituent and either a chloride or amine leaving group. It catalyses both deamination and dechlorination reactions.

History

created 2000 as EC 3.5.99.3, transferred 2016 to EC 3.5.4.43

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.2 With a heme protein as acceptor

1.6.3 With oxygen as acceptor

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.11.1 Peroxidases

1.11.2 Peroxygenases

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.23.1 With NADH or NADPH as donor

1.23.5 With a quinone or similar compound as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

3.1 Acting on ester bonds

3.2 Glycosylases

3.3 Acting on ether bonds

3.4 Acting on peptide bonds (peptidases)

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.2 In cyclic amides

3.5.3 In linear amidines

3.5.4 In cyclic amidines

3.5.4.1 cytosine deaminase

3.5.4.2 adenine deaminase

3.5.4.3 guanine deaminase

3.5.4.4 adenosine deaminase

3.5.4.5 cytidine deaminase

3.5.4.6 AMP deaminase

3.5.4.7 ADP deaminase

3.5.4.8 aminoimidazolase

3.5.4.9 methenyltetrahydrofolate cyclohydrolase

3.5.4.10 IMP cyclohydrolase

3.5.4.11 pterin deaminase

3.5.4.12 dCMP deaminase

3.5.4.13 dCTP deaminase

3.5.4.14 deoxycytidine deaminase

3.5.4.15 guanosine deaminase

3.5.4.16 GTP cyclohydrolase I

3.5.4.17 adenosine-phosphate deaminase

3.5.4.18 ATP deaminase

3.5.4.19 phosphoribosyl-AMP cyclohydrolase

3.5.4.20 pyrithiamine deaminase

3.5.4.21 creatinine deaminase

3.5.4.22 1-pyrroline-4-hydroxy-2-carboxylate deaminase

3.5.4.23 blasticidin-S deaminase

3.5.4.24 sepiapterin deaminase

3.5.4.25 GTP cyclohydrolase II

3.5.4.26 diaminohydroxyphosphoribosylaminopyrimidine deaminase

3.5.4.27 methenyltetrahydromethanopterin cyclohydrolase

3.5.4.28 S-adenosylhomocysteine deaminase

3.5.4.29 GTP cyclohydrolase IIa

3.5.4.30 dCTP deaminase (dUMP-forming)

3.5.4.31 S-methyl-5′-thioadenosine deaminase

3.5.4.32 8-oxoguanine deaminase

3.5.4.33 tRNA(adenine³⁴) deaminase

3.5.4.34 tRNA^Ala(adenine³⁷) deaminase

3.5.4.35 tRNA(cytosine⁸) deaminase

3.5.4.36 mRNA(cytosine⁶⁶⁶⁶) deaminase

3.5.4.37 double-stranded RNA adenine deaminase

3.5.4.38 single-stranded DNA cytosine deaminase

3.5.4.39 GTP cyclohydrolase IV

3.5.4.40 aminodeoxyfutalosine deaminase

3.5.4.41 5′-deoxyadenosine deaminase

3.5.4.42 N-isopropylammelide isopropylaminohydrolase

3.5.4.43 hydroxydechloroatrazine ethylaminohydrolase

3.5.4.44 ectoine hydrolase

3.5.4.45 melamine deaminase

3.5.4.46 cAMP deaminase

3.5.5 In nitriles

3.5.99 In other compounds

3.6 Acting on acid anhydrides

3.7 Acting on carbon-carbon bonds

3.8 Acting on halide bonds

3.9 Acting on phosphorus-nitrogen bonds

3.10 Acting on sulfur-nitrogen bonds

3.11 Acting on carbon-phosphorus bonds

3.12 Acting on sulfur-sulfur bonds

3.13 Acting on carbon-sulfur bonds

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)