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EC 1.3.1.118 Details

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EC number

1.3.1.118

Accepted name

meromycolic acid enoyl-[acyl-carrier-protein] reductase

Reaction

a meromycolyl-[acyl-carrier protein] + NAD⁺ = a trans-Δ²-meromycolyl-[acyl-carrier protein] + NADH + H⁺

Other name(s)

inhA (gene name)

Systematic name

meromycolyl-[acyl-carrier protein]:NAD⁺ oxidoreductase

Comment

InhA is a component of the fatty acid synthase (FAS) II system of Mycobacterium tuberculosis, catalysing an enoyl-[acyl-carrier-protein] reductase step. The enzyme acts on very long and unsaturated fatty acids that form the meromycolic component of mycolic acids. It extends FASI-derived C₂₀ fatty acids to form C₆₀ to C₉₀ mycolic acids. The enzyme, which forms a homotetramer, is the target of the preferred antitubercular drug isoniazid.

History

created 2018

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.1 dihydropyrimidine dehydrogenase (NAD⁺)

1.3.1.2 dihydropyrimidine dehydrogenase (NADP⁺)

1.3.1.3 Δ⁴-3-oxosteroid 5β-reductase

1.3.1.4 cortisone α-reductase

1.3.1.5 cucurbitacin Δ²³-reductase

1.3.1.6 fumarate reductase (NADH)

1.3.1.7 meso-tartrate dehydrogenase

1.3.1.8 acyl-CoA dehydrogenase (NADP⁺)

1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)

1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)

1.3.1.11 2-coumarate reductase

1.3.1.12 prephenate dehydrogenase

1.3.1.13 prephenate dehydrogenase (NADP⁺)

1.3.1.14 dihydroorotate dehydrogenase (NAD⁺)

1.3.1.15 dihydroorotate dehydrogenase (NADP⁺)

1.3.1.16 β-nitroacrylate reductase

1.3.1.17 3-methyleneoxindole reductase

1.3.1.18 kynurenate-7,8-dihydrodiol dehydrogenase

1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase

1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1.3.1.21 7-dehydrocholesterol reductase

1.3.1.22 3-oxo-5α-steroid 4-dehydrogenase (NADP⁺)

1.3.1.23 created 1972, deleted 2005

1.3.1.24 biliverdin reductase

1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase

1.3.1.26 dihydrodipicolinate reductase

1.3.1.27 2-hexadecenal reductase

1.3.1.28 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase

1.3.1.30 progesterone 5α-reductase

1.3.1.31 2-enoate reductase

1.3.1.32 maleylacetate reductase

1.3.1.33 protochlorophyllide reductase

1.3.1.34 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]

1.3.1.35 phosphatidylcholine desaturase

1.3.1.36 geissoschizine dehydrogenase

1.3.1.37 cis-2-enoyl-CoA reductase (NADPH)

1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)

1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)

1.3.1.40 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase

1.3.1.41 xanthommatin reductase

1.3.1.42 12-oxophytodienoate reductase

1.3.1.43 arogenate dehydrogenase

1.3.1.44 trans-2-enoyl-CoA reductase (NAD⁺)

1.3.1.45 2′-hydroxyisoflavone reductase

1.3.1.46 biochanin-A reductase

1.3.1.47 α-santonin 1,2-reductase

1.3.1.48 13,14-dehydro-15-oxoprostaglandin 13-reductase

1.3.1.49 cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase

1.3.1.50 created 1992, deleted 1999

1.3.1.51 2′-hydroxydaidzein reductase

1.3.1.52 2-methyl-branched-chain-enoyl-CoA reductase

1.3.1.53 (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase

1.3.1.54 precorrin-6A reductase

1.3.1.55 created 1999, deleted 2004

1.3.1.56 cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase

1.3.1.57 phloroglucinol reductase

1.3.1.58 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase

1.3.1.59 1,2-dihydroxy-3-methyl-1,2-dihydrobenzoate dehydrogenase

1.3.1.60 dibenzothiophene dihydrodiol dehydrogenase

1.3.1.61 terephthalate 1,2-cis-dihydrodiol dehydrogenase

1.3.1.62 pimeloyl-CoA dehydrogenase

1.3.1.63 2,4-dichlorobenzoyl-CoA reductase

1.3.1.64 phthalate 4,5-cis-dihydrodiol dehydrogenase

1.3.1.65 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase

1.3.1.66 cis-dihydroethylcatechol dehydrogenase

1.3.1.67 cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase

1.3.1.68 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase

1.3.1.69 zeatin reductase

1.3.1.70 Δ¹⁴-sterol reductase

1.3.1.71 Δ^24(24¹)-sterol reductase

1.3.1.72 Δ²⁴-sterol reductase

1.3.1.73 1,2-dihydrovomilenine reductase

1.3.1.74 2-alkenal reductase [NAD(P)⁺]

1.3.1.75 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)

1.3.1.76 precorrin-2 dehydrogenase

1.3.1.77 anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming]

1.3.1.78 arogenate dehydrogenase (NADP⁺)

1.3.1.79 arogenate dehydrogenase [NAD(P)⁺]

1.3.1.80 red chlorophyll catabolite reductase

1.3.1.81 (+)-pulegone reductase

1.3.1.82 (-)-isopiperitenone reductase

1.3.1.83 geranylgeranyl diphosphate reductase

1.3.1.84 acrylyl-CoA reductase (NADPH)

1.3.1.85 crotonyl-CoA carboxylase/reductase

1.3.1.86 crotonyl-CoA reductase

1.3.1.87 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase

1.3.1.88 tRNA-dihydrouridine^16/17 synthase [NAD(P)⁺]

1.3.1.89 tRNA-dihydrouridine⁴⁷ synthase [NAD(P)⁺]

1.3.1.90 tRNA-dihydrouridine^20a/20b synthase [NAD(P)⁺]

1.3.1.91 tRNA-dihydrouridine²⁰ synthase [NAD(P)⁺]

1.3.1.92 artemisinic aldehyde Δ¹¹⁽¹³⁾-reductase

1.3.1.93 very-long-chain enoyl-CoA reductase

1.3.1.94 polyprenol reductase

1.3.1.95 acrylyl-CoA reductase (NADH)

1.3.1.96 Botryococcus squalene synthase

1.3.1.97 botryococcene synthase

1.3.1.98 UDP-N-acetylmuramate dehydrogenase

1.3.1.99 (S)-8-oxocitronellyl enol synthase

1.3.1.100 chanoclavine-I aldehyde reductase

1.3.1.101 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H]

1.3.1.102 2-alkenal reductase (NADP⁺)

1.3.1.103 2-haloacrylate reductase

1.3.1.104 enoyl-[acyl-carrier-protein] reductase (NADPH)

1.3.1.105 2-methylene-furan-3-one reductase

1.3.1.106 cobalt-precorrin-6A reductase

1.3.1.107 sanguinarine reductase

1.3.1.108 caffeoyl-CoA reductase

1.3.1.109 butanoyl-CoA dehydrogenase complex (NAD⁺, ferredoxin)

1.3.1.110 lactate dehydrogenase (NAD⁺,ferredoxin)

1.3.1.111 geranylgeranyl-bacteriochlorophyllide a reductase

1.3.1.112 anthocyanidin reductase [(2S)-flavan-3-ol-forming]

1.3.1.113 (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase

1.3.1.114 3-dehydro-bile acid Δ^4,6-reductase

1.3.1.115 3-oxocholoyl-CoA 4-desaturase

1.3.1.116 7β-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase

1.3.1.117 hydroxycinnamoyl-CoA reductase

1.3.1.118 meromycolic acid enoyl-[acyl-carrier-protein] reductase

1.3.1.119 chlorobenzene dihydrodiol dehydrogenase

1.3.1.120 cyclohexane-1-carbonyl-CoA reductase (NADP⁺)

1.3.1.121 4-amino-4-deoxyprephenate dehydrogenase

1.3.1.122 (S)-8-oxocitronellyl enol synthase

1.3.1.123 8-oxogeranial reductase

1.3.1.124 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

1.3.2 With a cytochrome as acceptor

1.3.3 With oxygen as acceptor

1.3.4 With a disulfide as acceptor

1.3.5 With a quinone or related compound as acceptor

1.3.7 With an iron-sulfur protein as acceptor

1.3.8 With a flavin as acceptor

1.3.98 With other, known, physiological acceptors

1.3.99 With unknown physiological acceptors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.2 With a heme protein as acceptor

1.6.3 With oxygen as acceptor

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.11.1 Peroxidases

1.11.1.1 NADH peroxidase

1.11.1.2 NADPH peroxidase

1.11.1.3 fatty-acid peroxidase

1.11.1.4 created 1961, deleted 1964, reinstated 1965 as EC 1.13.1.12, deleted 1972

1.11.1.5 cytochrome-c peroxidase

1.11.1.6 catalase

1.11.1.7 peroxidase

1.11.1.8 iodide peroxidase

1.11.1.9 glutathione peroxidase

1.11.1.10 chloride peroxidase

1.11.1.11 L-ascorbate peroxidase

1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase

1.11.1.13 manganese peroxidase

1.11.1.14 lignin peroxidase

1.11.1.15 peroxiredoxin

1.11.1.16 versatile peroxidase

1.11.1.17 glutathione amide-dependent peroxidase

1.11.1.18 bromide peroxidase

1.11.1.19 dye decolorizing peroxidase

1.11.1.20 prostamide/prostaglandin F_2α synthase

1.11.1.21 catalase-peroxidase

1.11.1.22 hydroperoxy fatty acid reductase

1.11.1.23 (S)-2-hydroxypropylphosphonic acid epoxidase

1.11.1.24 thioredoxin-dependent peroxiredoxin

1.11.1.25 glutaredoxin-dependent peroxiredoxin

1.11.1.26 NADH-dependent peroxiredoxin

1.11.1.27 glutathione-dependent peroxiredoxin

1.11.1.28 lipoyl-dependent peroxiredoxin

1.11.1.29 mycoredoxin-dependent peroxiredoxin

1.11.2 Peroxygenases

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)