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EC 1.14.14.89 Details
show Brenda entryEC number
1.14.14.89
Accepted name
4′-methoxyisoflavone 2′-hydroxylase
Reaction
formononetin + [reduced NADPH—hemoprotein reductase] + O2 = 2′-hydroxyformononetin + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
CYP81E1 (gene name),
CYP81E3 (gene name),
CYP81E7 (gene name),
isoflavone 2′-monooxygenase (ambiguous),
isoflavone 2′-hydroxylase (ambiguous)
Systematic name
formononetin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (2′-hydroxylating)
CAS registry number
110183-49-8
Comment
A cytochrome P-450 (heme-thiolate) protein. Acts on isoflavones with a 4′-methoxy group, such as formononetin and biochanin A. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. EC 1.14.14.90, isoflavone 2′-hydroxylase, is less specific and acts on other isoflavones as well as 4′-methoxyisoflavones.
History
created 1992 as EC 1.14.13.53, modified 2005, transferred 2018 to EC 1.14.14.89
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
