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EC 1.14.14.44 Details
show Brenda entryEC number
1.14.14.44
Accepted name
phenylacetaldehyde oxime monooxygenase
Reaction
(E)-phenylacetaldehyde oxime + [reduced NADPH—hemoprotein reductase] + O2 = (R)-mandelonitrile + [oxidized NADPH—hemoprotein reductase] + 2 H2O (overall reaction);;(1a) (E)-phenylacetaldehyde oxime = (Z)-phenylacetaldehyde oxime;;(1b) (Z)-phenylacetaldehyde oxime = phenylacetonitrile + H2O;;(1c) phenylacetonitrile + [reduced NADPH—hemoprotein reductase] + O2 = (R)-mandelonitrile + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
CYP71AN24 (gene name)
Systematic name
(E)-phenylacetaldehyde oxime,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase
Comment
This cytochrome P-450 (heme-thiolate) enzyme is involved in the biosynthesis of the cyanogenic glucosides (R)-prunasin and (R)-amygdalin. It catalyses three different activities - isomerization of the (E) isomer to the (Z) isomer, dehydration, and C-hydroxylation.
History
created 2017
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
