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EC 1.3.1.22 Details
EC number
1.3.1.22
Accepted name
3-oxo-5α-steroid 4-dehydrogenase (NADP+)
Reaction
a 3-oxo-5α-steroid + NADP+ = a 3-oxo-Δ4-steroid + NADPH + H+
Other name(s)
cholestenone 5α-reductase,
testosterone Δ4-5α-reductase,
steroid 5α-reductase,
3-oxosteroid Δ4-dehydrogenase,
5α-reductase,
steroid 5α-hydrogenase,
3-oxosteroid 5α-reductase,
testosterone Δ4-hydrogenase,
4-ene-3-oxosteroid 5α-reductase,
reduced nicotinamide adenine dinucleotide phosphate:Δ4-3-ketosteroid 5α-oxidoreductase,
4-ene-5α-reductase,
Δ4-3-ketosteroid 5α-oxidoreductase,
cholest-4-en-3-one 5α-reductase,
testosterone 5α-reductase,
3-oxo-5α-steroid 4-dehydrogenase
Systematic name
3-oxo-5α-steroid:NADP+ Δ4-oxidoreductase
CAS registry number
37255-34-8
Comment
The enzyme catalyses the conversion of assorted 3-oxo-Δ4 steroids into their corresponding 5α form. Substrates for the mammalian enzyme include testosterone, progesterone, and corticosterone. Substrates for the plant enzyme are brassinosteroids such as campest-4-en-3-one and (22α)-hydroxy-campest-4-en-3-one. cf. EC 1.3.99.5, 3-oxo-5α-steroid 4-dehydrogenase (acceptor).
History
created 1972, modified 2012
EC Tree
1.3.1.23 created 1972, deleted 2005
1.3.1.50 created 1992, deleted 1999
1.3.1.55 created 1999, deleted 2004