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EC 3.4.22.46 Details
EC number
3.4.22.46
Accepted name
L-peptidase
Reaction
Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys┼Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly┼Arg- and -Lys┼Arg-
Comment
Best known from foot-and-mouth disease virus, but occurs in other aphthoviruses and cardioviruses. Destruction of initiation factor eIF-4G has the effect of shutting off host-cell protein synthesis while allowing synthesis of viral proteins to continue. The tertiary structure reveals a distant relationship to papain and, consistent with this, compound E-64 is inhibitory. Type example of peptidase family C28.
History
created 2001
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EC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.2 Acting on the aldehyde or oxo group of donors
1.3 Acting on the CH-CH group of donors
1.3.1 With NAD+ or NADP+ as acceptor
1.3.2 With a cytochrome as acceptor
1.3.3 With oxygen as acceptor
1.3.4 With a disulfide as acceptor
1.3.5 With a quinone or related compound as acceptor
1.3.7 With an iron-sulfur protein as acceptor
1.3.8 With a flavin as acceptor
1.3.98 With other, known, physiological acceptors
1.3.99 With unknown physiological acceptors
1.4 Acting on the CH-NH2 group of donors
1.5 Acting on the CH-NH group of donors
1.6 Acting on NADH or NADPH
1.7 Acting on other nitrogenous compounds as donors
1.8 Acting on a sulfur group of donors
1.9 Acting on a heme group of donors
1.10 Acting on diphenols and related substances as donors
1.11 Acting on a peroxide as acceptor
1.12 Acting on hydrogen as donor
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.15 Acting on superoxide as acceptor
1.15.1 Acting on superoxide as acceptor (only sub-subclass identified to date)
1.16 Oxidizing metal ions
1.17 Acting on CH or CH2 groups
1.18 Acting on iron-sulfur proteins as donors
1.19 Acting on reduced flavodoxin as donor
1.20 Acting on phosphorus or arsenic in donors
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.21.1 With NAD+ or NADP+ as acceptor
1.21.3 With oxygen as acceptor
1.21.4 With a disulfide as acceptor
1.21.98 With other, known, physiological acceptors
1.21.99 With unknown physiological acceptors
1.22 Acting on halogen in donors
1.23 Reducing C-O-C group as acceptor
1.97 Other oxidoreductases
1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses
1.98 Enzymes using H2 as reductant (deleted subclass)
1.99 Other enzymes using O2 as oxidant (deleted subclass)
2 Transferases
2.1 Transferring one-carbon groups
2.2 Transferring aldehyde or ketonic groups
2.3 Acyltransferases
2.4 Glycosyltransferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.6 Transferring nitrogenous groups
2.7 Transferring phosphorus-containing groups
2.8 Transferring sulfur-containing groups
2.9 Transferring selenium-containing groups
2.10 Transferring molybdenum- or tungsten-containing groups
3 Hydrolases
3.1 Acting on ester bonds
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.4.1 α-Amino-acyl-peptide hydrolases (deleted sub-subclass)
3.4.2 Peptidyl-amino-acid hydrolases (deleted sub-subclass)
3.4.3 Dipeptide hydrolases (deleted sub-subclass)
3.4.4 Peptidyl peptide hydrolases (deleted sub-subclass)
3.4.11 Aminopeptidases
3.4.12 Peptidylamino-acid hydrolases or acylamino-acid hydrolases (deleted sub-subclass)
3.4.13 Dipeptidases
3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
3.4.15 Peptidyl-dipeptidases
3.4.16 Serine-type carboxypeptidases
3.4.17 Metallocarboxypeptidases
3.4.18 Cysteine-type carboxypeptidases
3.4.19 Omega peptidases
3.4.21 Serine endopeptidases
3.4.22 Cysteine endopeptidases
3.4.22.1 cathepsin B
3.4.22.2 papain
3.4.22.3 ficain
3.4.22.4 created 1972, deleted 1992 [EC 3.4.22.5 created 1972, incorporated 1978]
3.4.22.5 created 1972, deleted 1978
3.4.22.6 chymopapain
3.4.22.7 asclepain
3.4.22.8 clostripain
3.4.22.9 created 1972, deleted 1981
3.4.22.10 streptopain
3.4.22.11 created 1976, deleted 1978 [transferred to EC 3.4.99.45, deleted 1993]
3.4.22.12 created 1978, deleted 1992
3.4.22.13 created 1978, modified 1981, deleted 1992
3.4.22.14 actinidain
3.4.22.15 cathepsin L
3.4.22.16 cathepsin H
3.4.22.17 created 1981 [EC 3.4.24.5 created 1978, part incorporated 1989], deleted 2003
3.4.22.18 created 1981, deleted 1992
3.4.22.19 created 1989, deleted 1992
3.4.22.20 created 1989, deleted 1992
3.4.22.21 created 1989, deleted 1992
3.4.22.22 created 1989, deleted 1992
3.4.22.23 created 1989, deleted 1992
3.4.22.24 cathepsin T
3.4.22.25 glycyl endopeptidase
3.4.22.26 cancer procoagulant
3.4.22.27 cathepsin S
3.4.22.28 picornain 3C
3.4.22.29 picornain 2A
3.4.22.30 caricain
3.4.22.31 ananain
3.4.22.32 stem bromelain
3.4.22.33 fruit bromelain
3.4.22.34 legumain
3.4.22.35 histolysain
3.4.22.36 caspase-1
3.4.22.37 gingipain R
3.4.22.38 cathepsin K
3.4.22.39 adenain
3.4.22.40 bleomycin hydrolase
3.4.22.41 cathepsin F
3.4.22.42 cathepsin O
3.4.22.43 cathepsin V
3.4.22.44 nuclear-inclusion-a endopeptidase
3.4.22.45 helper-component proteinase
3.4.22.46 L-peptidase
3.4.22.47 gingipain K
3.4.22.48 staphopain
3.4.22.49 separase
3.4.22.50 V-cath endopeptidase
3.4.22.51 cruzipain
3.4.22.52 calpain-1
3.4.22.53 calpain-2
3.4.22.54 calpain-3
3.4.22.55 caspase-2
3.4.22.56 caspase-3
3.4.22.57 caspase-4
3.4.22.58 caspase-5
3.4.22.59 caspase-6
3.4.22.60 caspase-7
3.4.22.61 caspase-8
3.4.22.62 caspase-9
3.4.22.63 caspase-10
3.4.22.64 caspase-11
3.4.22.65 peptidase 1 (mite)
3.4.22.66 calicivirin
3.4.22.67 zingipain
3.4.22.68 Ulp1 peptidase
3.4.22.69 SARS coronavirus main proteinase
3.4.22.70 sortase A
3.4.22.71 sortase B
3.4.23 Aspartic endopeptidases
3.4.24 Metalloendopeptidases
3.4.25 Threonine endopeptidases
3.4.99 Endopeptidases of unknown catalytic mechanism (sub-subclass is currently empty)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
5.1 Racemases and epimerases
5.2 cis-trans-Isomerases
5.3 Intramolecular oxidoreductases
5.4 Intramolecular transferases
5.5 Intramolecular lyases
5.6 Isomerases altering macromolecular conformation
5.99 Other isomerases
6 Ligases
7 Translocases