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Information on EC - L-peptidase

for references in articles please use BRENDA:EC3.4.22.46
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
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Word Map
The enzyme appears in viruses and cellular organisms
l protein, 3c protease, 3cpro, l proteinase, leader protease, nsp1alpha, lab protein, p1a protein, fmdv 3cpro, leader peptidase b, more
autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-/-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-/-Arg- and -Lys-/-Arg-
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Best known from foot-and-mouth disease virus, but occurs in other aphthoviruses and cardioviruses. Destruction of initiation factor eIF-4G has the effect of shutting off host-cell protein synthesis while allowing synthesis of viral proteins to continue. The tertiary structure reveals a distant relationship to papain and, consistent with this, compound E-64 is inhibitory. Type example of peptidase family C28
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