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EC 3.4.14.10 Details

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EC number

3.4.14.10

Accepted name

tripeptidyl-peptidase II

Reaction

Release of an N-terminal tripeptide from a polypeptide

Other name(s)

tripeptidyl aminopeptidase, tripeptidyl peptidase, tripeptidyl aminopeptidase II, tripeptidyl peptidase II, TPP

CAS registry number

101149-94-4

Comment

A cytosolic enzyme in peptidase family S8 (subtilisin family). Active at neutral pH. Inhibited by diisopropyl fluorophosphate. Formerly included in EC 3.4.14.8

History

created 1992 (part of EC 3.4.14.8 created 1989, incorporated 1992)

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.2 With a cytochrome as acceptor

1.3.3 With oxygen as acceptor

1.3.4 With a disulfide as acceptor

1.3.5 With a quinone or related compound as acceptor

1.3.7 With an iron-sulfur protein as acceptor

1.3.8 With a flavin as acceptor

1.3.98 With other, known, physiological acceptors

1.3.99 With unknown physiological acceptors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.15.1 Acting on superoxide as acceptor (only sub-subclass identified to date)

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups

3.1 Acting on ester bonds

3.2 Glycosylases

3.3 Acting on ether bonds

3.4 Acting on peptide bonds (peptidases)

3.4.1 α-Amino-acyl-peptide hydrolases (deleted sub-subclass)

3.4.2 Peptidyl-amino-acid hydrolases (deleted sub-subclass)

3.4.3 Dipeptide hydrolases (deleted sub-subclass)

3.4.4 Peptidyl peptide hydrolases (deleted sub-subclass)

3.4.11 Aminopeptidases

3.4.12 Peptidylamino-acid hydrolases or acylamino-acid hydrolases (deleted sub-subclass)

3.4.13 Dipeptidases

3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

3.4.14.1 dipeptidyl-peptidase I

3.4.14.2 dipeptidyl-peptidase II

3.4.14.3 created 1978, deleted 1981

3.4.14.4 dipeptidyl-peptidase III

3.4.14.5 dipeptidyl-peptidase IV

3.4.14.6 dipeptidyl-dipeptidase

3.4.14.7 created 1989, deleted 1992

3.4.14.8 created 1989, deleted 1992

3.4.14.9 tripeptidyl-peptidase I

3.4.14.10 tripeptidyl-peptidase II

3.4.14.11 Xaa-Pro dipeptidyl-peptidase

3.4.14.12 Xaa-Xaa-Pro tripeptidyl-peptidase

3.4.14.13 γ-D-glutamyl-L-lysine dipeptidyl-peptidase

3.4.14.14 [mycofactocin precursor peptide] peptidase

3.4.15 Peptidyl-dipeptidases

3.4.16 Serine-type carboxypeptidases

3.4.17 Metallocarboxypeptidases

3.4.18 Cysteine-type carboxypeptidases

3.4.19 Omega peptidases

3.4.21 Serine endopeptidases

3.4.22 Cysteine endopeptidases

3.4.23 Aspartic endopeptidases

3.4.24 Metalloendopeptidases

3.4.25 Threonine endopeptidases

3.4.99 Endopeptidases of unknown catalytic mechanism (sub-subclass is currently empty)

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.6 Acting on acid anhydrides

3.7 Acting on carbon-carbon bonds

3.8 Acting on halide bonds

3.9 Acting on phosphorus-nitrogen bonds

3.10 Acting on sulfur-nitrogen bonds

3.11 Acting on carbon-phosphorus bonds

3.12 Acting on sulfur-sulfur bonds

3.13 Acting on carbon-sulfur bonds

5.1 Racemases and epimerases

5.2 cis-trans-Isomerases

5.3 Intramolecular oxidoreductases

5.4 Intramolecular transferases

5.5 Intramolecular lyases

5.6 Isomerases altering macromolecular conformation

5.99 Other isomerases

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Release 2023.1 (January 2023)