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EC 3.4.14.4 Details
EC number
3.4.14.4
Accepted name
dipeptidyl-peptidase III
Reaction
Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.
Other name(s)
dipeptidyl aminopeptidase III,
dipeptidyl arylamidase III,
enkephalinase B,
red cell angiotensinase
CAS registry number
77464-87-0
Comment
A cytosolic peptidase that is active at neutral pH. It has broad activity on peptides, although it is highly selective for Arg-Arg-2-naphthylamide, at pH 9.2. Active in the hydrolysis of enkephalins. A metallopeptidase, the type example of peptidase family M49.
History
created 1981, modified 2001
EC Tree
3.4.14.3 created 1978, deleted 1981
3.4.14.7 created 1989, deleted 1992
3.4.14.8 created 1989, deleted 1992