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EC 3.4.11.24 Details
EC number
3.4.11.24
Accepted name
aminopeptidase S
Reaction
Release of an N-terminal amino acid with a preference for large hydrophobic amino-terminus residues
Other name(s)
Mername-AA022 peptidase,
SGAP,
aminopeptidase (Streptomyces griseus),
Streptomyces griseus aminopeptidase,
S. griseus AP,
double-zinc aminopeptidase
Comment
Aminopeptidases are associated with many biological functions, including protein maturation, protein degradation, cell-cycle control and hormone-level regulation [3,4]. This enzyme contains two zinc molecules in its active site and is activated by Ca2+ [4]. In the presence of Ca2+, the best substrates are Leu-Phe, Leu-Ser, Leu-pNA (aminoacyl-p-nitroanilide), Phe-Phe-Phe and Phe-Phe [3]. Peptides with proline in the P1′ position are not substrates [3]. Belongs in peptidase family M28.
History
created 2008
EC Tree
3.4.11.8 created 1972, deleted 1981
3.4.11.11 created 1978, deleted 1992
3.4.11.12 created 1978, deleted 1997