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EC 1.14.19.66 Details
show Brenda entryEC number
1.14.19.66
Accepted name
berbamunine synthase
Reaction
(S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH—hemoprotein reductase] + O2 = berbamunine + [oxidized NADPH—hemoprotein reductase] + 2 H2O
Other name(s)
(S)-N-methylcoclaurine oxidase (C-O phenol-coupling)
Systematic name
(S)-N-methylcoclaurine,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (C-O phenol-coupling)
CAS registry number
144941-42-4
Comment
A cytochrome P-450 (heme-thiolate) protein found in plants. Forms the bisbenzylisoquinoline alkaloid berbamunine by phenol oxidation of N-methylcoclaurine without the incorporation of oxygen into the product. Reaction of two molecules of (R)-N-methylcoclaurine gives the dimer guattagaumerine.
History
created 1999 as EC 1.1.3.34, transferred 2002 to EC 1.14.21.3, transferred 2018 to EC 1.14.19.66
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.2.1 created 1961, deleted 1965 1.6.2.3 created 1972, deleted 1965
