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Information on EC 1.14.19.66 - berbamunine synthase

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IUBMB Comments
A cytochrome P-450 (heme-thiolate) protein found in plants. Forms the bisbenzylisoquinoline alkaloid berbamunine by phenol oxidation of N-methylcoclaurine without the incorporation of oxygen into the product. Reaction of two molecules of (R)-N-methylcoclaurine gives the dimer guattagaumerine.
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The expected taxonomic range for this enzyme is: Berberis stolonifera
Synonyms
(S)-N-methylcoclaurine oxidase (C-O phenol-coupling), (S)-N-methylcoclaurine oxidase [C-O phenol-coupling], benzyltetrahydroisoquinoline oxidase, CYP80, CYPLXXX, Cytochrome P450 80, EC 1.1.3.34, oxidase, benzyltetrahydroisoquinoline, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
(S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 = berbamunine + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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