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EC 1.21.99.5 Details

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EC number

1.21.99.5

Accepted name

tetrachloroethene reductive dehalogenase

Reaction

trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor

Other name(s)

tetrachloroethene reductase

Systematic name

acceptor:trichloroethene oxidoreductase (chlorinating)

CAS registry number

163913-51-7

Comment

This enzyme allows the common pollutant tetrachloroethene to support bacterial growth and is responsible for disposal of a number of chlorinated hydrocarbons. The reaction occurs in the reverse direction. The enzyme also reduces trichloroethene to dichloroethene. Although the physiological reductant is unknown, the supply of reductant in some organisms involves menaquinol, which is reduced by molecular hydrogen via the action of EC 1.12.5.1, hydrogen:quinone oxidoreductase. The enzyme contains a corrinoid and two iron-sulfur clusters. Methyl viologen can act as electron donor in vitro.

History

created 2001 as EC 1.97.1.8, transferred 2017 to EC 1.21.99.5

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.2 With a heme protein as acceptor

1.6.3 With oxygen as acceptor

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.8.1 created 1981, deleted 2002

1.6.8.2 created 1982, deleted 2002

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.3.1 isopenicillin-N synthase

1.21.3.2 columbamine oxidase

1.21.3.3 reticuline oxidase

1.21.3.4 sulochrin oxidase [(+)-bisdechlorogeodin-forming]

1.21.3.5 sulochrin oxidase [(-)-bisdechlorogeodin-forming]

1.21.3.6 aureusidin synthase

1.21.3.7 tetrahydrocannabinolic acid synthase

1.21.3.8 cannabidiolic acid synthase

1.21.3.9 dichlorochromopyrrolate synthase

1.21.3.10 hercynylcysteine S-oxide synthase

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.21.99.1 β-cyclopiazonate dehydrogenase

1.21.99.2 cyclic dehypoxanthinyl futalosine synthase

1.21.99.3 thyroxine 5-deiodinase

1.21.99.4 thyroxine 5′-deiodinase

1.21.99.5 tetrachloroethene reductive dehalogenase

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)