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Information on EC 1.21.99.5 - tetrachloroethene reductive dehalogenase

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IUBMB Comments
This enzyme allows the common pollutant tetrachloroethene to support bacterial growth and is responsible for disposal of a number of chlorinated hydrocarbons. The reaction occurs in the reverse direction. The enzyme also reduces trichloroethene to dichloroethene. Although the physiological reductant is unknown, the supply of reductant in some organisms involves menaquinol, which is reduced by molecular hydrogen via the action of EC 1.12.5.1, hydrogen:quinone oxidoreductase. The enzyme contains a corrinoid and two iron-sulfur clusters. Methylviologen can act as electron donor in vitro.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
reductive dehalogenase, rdase, pce dehalogenase, pce reductive dehalogenase, tetrachloroethene (pce) reductive dehalogenase, tetrachloroethene dehalogenase, pce-reductive dehalogenase, pcea1, ssed_3769, rdha3, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor
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