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EC 5.6.1.1 Details

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EC number

5.6.1.1

Accepted name

microtubule-severing ATPase

Reaction

n ATP + n H₂O + a microtubule = n ADP + n phosphate + (n+1) α/β tubulin heterodimers

Other name(s)

katanin

Systematic name

ATP phosphohydrolase (tubulin-dimerizing)

Comment

A member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.

History

created 2000 as 3.6.4.3, transferred 2018 to EC 5.6.1.1

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.17.1 With NAD⁺ or NADP⁺ as acceptor

1.17.2 With a cytochrome as acceptor

1.17.3 With oxygen as acceptor

1.17.4 With a disulfide as acceptor

1.17.5 With a quinone or similar compound as acceptor

1.17.7 With an iron-sulfur protein as acceptor

1.17.8 With a flavin as acceptor

1.17.9 With a copper protein as acceptor

1.17.98 With other, known, physiological acceptors

1.17.99 With unknown physiological acceptors

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

5.6.1.1 microtubule-severing ATPase

5.6.1.2 dynein ATPase

5.6.1.3 plus-end-directed kinesin ATPase

5.6.1.4 minus-end-directed kinesin ATPase

5.6.1.5 proteasome ATPase

5.6.1.6 channel-conductance-controlling ATPase

5.6.1.7 chaperonin ATPase

5.6.1.8 myosin ATPase

5.6.1.9 (R)-2-hydroxyacyl-CoA dehydratase activating ATPase

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Release 2023.1 (January 2023)