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EC 1.11.1.23 Details
show Brenda entryEC number
1.11.1.23
Accepted name
(S)-2-hydroxypropylphosphonic acid epoxidase
Reaction
(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-1,2-epoxypropylphosphonate + 2 H2O
Other name(s)
HPP epoxidase,
HppE,
2-hydroxypropylphosphonic acid epoxidase,
Fom4,
(S)-2-hydroxypropylphosphonate epoxidase
Systematic name
(S)-2-hydroxypropylphosphonate:hydrogen-peroxide epoxidase
Comment
This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species. Contains non heme iron that forms a iron(IV)-oxo (ferryl) complex with hydrogen peroxide, which functions as a proton abstractor from the substrate [7].
History
created 2011 as EC 1.14.19.7, transferred 2014 to EC 1.11.1.23
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.3.1 created 1961, deleted 1984 1.1.3.25 created 1986, deleted 2005 1.1.3.26 created 1989, deleted 2002 1.1.3.31 created 1992, deleted 2003 1.1.3.32 created 1999, deleted 2002 1.1.3.33 created 1999, deleted 2002 1.1.3.34 created 1999, deleted 2002 1.1.3.35 created 1999, deleted 2002 1.1.3.36 created 1999, deleted 2002 1.1.99.15 created 1978, deleted 1980 1.1.99.17 created 1982, deleted 2003
