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EC 1.3.3.8 Details

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EC number

1.3.3.8

Accepted name

tetrahydroberberine oxidase

Reaction

(S)-tetrahydroberberine + 2 O₂ = berberine + 2 H₂O₂

Other name(s)

(S)-THB oxidase

Systematic name

(S)-tetrahydroberberine:oxygen oxidoreductase

CAS registry number

114705-00-9

Comment

The enzyme from Berberis sp. is a flavoprotein; that from Coptis japonica is not. (R)-Tetrahydroberberines are not oxidized.

History

created 1990 (EC 1.5.3.8 created 1989, incorporated 1992)

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.2 With a cytochrome as acceptor

1.1.3 With oxygen as acceptor

1.1.3.1 created 1961, deleted 1984

1.1.3.2 L-lactate oxidase

1.1.3.3 malate oxidase

1.1.3.4 glucose oxidase

1.1.3.5 hexose oxidase

1.1.3.6 cholesterol oxidase

1.1.3.7 aryl-alcohol oxidase

1.1.3.8 L-gulonolactone oxidase

1.1.3.9 galactose oxidase

1.1.3.10 pyranose oxidase

1.1.3.11 L-sorbose oxidase

1.1.3.12 pyridoxine 4-oxidase

1.1.3.13 alcohol oxidase

1.1.3.14 catechol oxidase (dimerizing)

1.1.3.15 (S)-2-hydroxy-acid oxidase

1.1.3.16 ecdysone oxidase

1.1.3.17 choline oxidase

1.1.3.18 secondary-alcohol oxidase

1.1.3.19 4-hydroxymandelate oxidase (decarboxylating)

1.1.3.20 long-chain-alcohol oxidase

1.1.3.21 glycerol-3-phosphate oxidase

1.1.3.22 created 1961 as EC 1.2.3.2, transferred 1984 to EC 1.1.3.22, modified 1989, deleted 2004

1.1.3.23 thiamine oxidase

1.1.3.24 L-galactonolactone oxidase

1.1.3.25 created 1986, deleted 2005

1.1.3.26 created 1989, deleted 2002

1.1.3.27 hydroxyphytanate oxidase

1.1.3.28 nucleoside oxidase

1.1.3.29 N-acylhexosamine oxidase

1.1.3.30 polyvinyl-alcohol oxidase

1.1.3.31 created 1992, deleted 2003

1.1.3.32 created 1999, deleted 2002

1.1.3.33 created 1999, deleted 2002

1.1.3.34 created 1999, deleted 2002

1.1.3.35 created 1999, deleted 2002

1.1.3.36 created 1999, deleted 2002

1.1.3.37 D-arabinono-1,4-lactone oxidase

1.1.3.38 vanillyl-alcohol oxidase

1.1.3.39 nucleoside oxidase (H₂O₂-forming)

1.1.3.40 D-mannitol oxidase

1.1.3.41 alditol oxidase

1.1.3.42 prosolanapyrone-II oxidase

1.1.3.43 paromamine 6′-oxidase

1.1.3.44 6′′′-hydroxyneomycin C oxidase

1.1.3.45 aclacinomycin-N oxidase

1.1.3.46 4-hydroxymandelate oxidase

1.1.3.47 5-(hydroxymethyl)furfural oxidase

1.1.3.48 3-deoxy-α-D-manno-octulosonate 8-oxidase

1.1.3.49 (R)-mandelonitrile oxidase

1.1.3.50 C-glycoside oxidase

1.1.4 With a disulfide as acceptor

1.1.5 With a quinone or similar compound as acceptor

1.1.7 With an iron-sulfur protein as acceptor

1.1.9 With a copper protein as acceptor

1.1.98 With other, known, physiological acceptors

1.1.99 With unknown physiological acceptors

1.1.99.1 choline dehydrogenase

1.1.99.2 L-2-hydroxyglutarate dehydrogenase

1.1.99.3 gluconate 2-dehydrogenase (acceptor)

1.1.99.4 dehydrogluconate dehydrogenase

1.1.99.5 glycerol-3-phosphate dehydrogenase

1.1.99.6 D-lactate dehydrogenase (acceptor)

1.1.99.7 lactate—malate transhydrogenase

1.1.99.8 alcohol dehydrogenase (acceptor)

1.1.99.9 pyridoxine 5-dehydrogenase

1.1.99.10 glucose dehydrogenase (acceptor)

1.1.99.11 fructose 5-dehydrogenase

1.1.99.12 sorbose dehydrogenase

1.1.99.13 glucoside 3-dehydrogenase (acceptor)

1.1.99.14 glycolate dehydrogenase

1.1.99.15 created 1978, deleted 1980

1.1.99.16 malate dehydrogenase (acceptor)

1.1.99.17 created 1982, deleted 2003

1.1.99.18 cellobiose dehydrogenase (acceptor)

1.1.99.19 uracil dehydrogenase

1.1.99.20 alkan-1-ol dehydrogenase (acceptor)

1.1.99.21 D-sorbitol dehydrogenase (acceptor)

1.1.99.22 glycerol dehydrogenase (acceptor)

1.1.99.23 polyvinyl-alcohol dehydrogenase (acceptor)

1.1.99.24 hydroxyacid-oxoacid transhydrogenase

1.1.99.25 quinate dehydrogenase (pyrroloquinoline-quinone)

1.1.99.26 3-hydroxycyclohexanone dehydrogenase

1.1.99.27 (R)-pantolactone dehydrogenase (flavin)

1.1.99.28 glucose-fructose oxidoreductase

1.1.99.29 pyranose dehydrogenase (acceptor)

1.1.99.30 2-oxo-acid reductase

1.1.99.31 (S)-mandelate dehydrogenase

1.1.99.32 L-sorbose 1-dehydrogenase

1.1.99.33 formate dehydrogenase (acceptor)

1.1.99.34 glucose-6-phosphate dehydrogenase (coenzyme-F₄₂₀)

1.1.99.35 soluble quinoprotein glucose dehydrogenase

1.1.99.36 alcohol dehydrogenase (nicotinoprotein)

1.1.99.37 methanol dehydrogenase (nicotinoprotein)

1.1.99.38 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)

1.1.99.39 D-2-hydroxyglutarate dehydrogenase

1.1.99.40 (R)-2-hydroxyglutarate—pyruvate transhydrogenase

1.1.99.41 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase

1.1.99.42 4-pyridoxic acid dehydrogenase

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.2 With a cytochrome as acceptor

1.3.3 With oxygen as acceptor

1.3.3.1 dihydroorotate oxidase

1.3.3.2 created 1972, deleted 2005

1.3.3.3 coproporphyrinogen oxidase

1.3.3.4 protoporphyrinogen oxidase

1.3.3.5 bilirubin oxidase

1.3.3.6 acyl-CoA oxidase

1.3.3.7 dihydrouracil oxidase

1.3.3.8 tetrahydroberberine oxidase

1.3.3.9 secologanin synthase

1.3.3.10 tryptophan α,β-oxidase

1.3.3.11 pyrroloquinoline-quinone synthase

1.3.3.12 L-galactonolactone oxidase

1.3.3.13 albonoursin synthase

1.3.3.14 aclacinomycin-A oxidase

1.3.3.15 coproporphyrinogen III oxidase (coproporphyrin-forming)

1.3.3.16 oxazoline dehydrogenase

1.3.3.17 benzylmalonyl-CoA dehydrogenase

1.3.4 With a disulfide as acceptor

1.3.5 With a quinone or related compound as acceptor

1.3.7 With an iron-sulfur protein as acceptor

1.3.8 With a flavin as acceptor

1.3.98 With other, known, physiological acceptors

1.3.99 With unknown physiological acceptors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)