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EC 1.1.1.298 Details
EC number
1.1.1.298
Accepted name
3-hydroxypropionate dehydrogenase (NADP+)
Reaction
3-hydroxypropanoate + NADP+ = malonate semialdehyde + NADPH + H+
Other name(s)
3-hydroxypropanoate dehydrogenase (NADP+),
3-hydroxypropionate:NADP+ oxidoreductase
Systematic name
3-hydroxypropanoate:NADP+ oxidoreductase
Comment
Catalyses the reduction of malonate semialdehyde to 3-hydroxypropanoate, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutanoate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and archaea, respectively [1,2]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the upstream reaction in the pathway, EC 1.2.1.75 [3]. Different from EC 1.1.1.59 [3-hydroxypropionate dehydrogenase (NAD+)] by cofactor preference.
History
created 2009
EC Tree
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