Any feedback?
No. of entries
Information on EC 1.1.1.59 - 3-hydroxypropionate dehydrogenase
for references in articles please use BRENDA:EC1.1.1.59
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.59 3-hydroxypropionate dehydrogenase
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
showSynonyms
hpd1p, 3-hydroxypropionate dehydrogenase, more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3-hydroxyisobutyrate dehydrogenase
3-hydroxyisobutyrate dehydrogenase
-
cf. EC1.1.1.31, wide substrate specificity (hydroxyacid derivatives)
3-hydroxyisobutyrate dehydrogenase
-
cf. EC1.1.1.31, wide substrate specificity (hydroxyacid derivatives)
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3-hydroxypropanoate + NAD+ = 3-oxopropanoate + NADH + H+
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
acrylate degradation I, beta-alanine biosynthesis II, propanoyl-CoA degradation II
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
3-hydroxypropanoate:NAD+ oxidoreductase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9028-59-5
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R)-3-hydroxyisobutyrate + NAD+
3-oxoisobutyrate + NADH + H+
Substrates: -
Products: -
Products: -
?
(S)-3-hydroxyisobutyrate + NAD+
3-oxoisobutyrate + NADH + H+
Substrates: -
Products: -
Products: -
?
3-hydroxyisobutyrate + NAD+
methylmalonate semialdehyde + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
malonate semialdehyde + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NADP+
malonate semialdehyde + NADPH + H+
-
Substrates: -
Products: -
Products: -
r
L-serine + NAD+
3-oxo-L-alanine + NADH + H+
Substrates: -
Products: -
Products: -
?
additional information
?
-
-
Substrates: MmsB from Bacillus cereus exhibits 3-hydroxyisobutyrate dehydrogenase, EC 1.1.1.31, as well as 3-hydroxypropionate dehydrogenase activity
Products: -
Products: -
?
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
Substrates: preferred substrate
Products: -
Products: -
?
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
Solidesulfovibrio alcoholivorans
-
Substrates: -
Products: -
Products: -
?
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
Substrates: MmsB from Bacillus cereus exhibits 3-hydroxyisobutyrate dehydrogenase, EC 1.1.1.31, as well as 3-hydroxypropionate dehydrogenase activity
Products: -
Products: -
?
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
Substrates: preferred substrate
Products: -
Products: -
?
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
3-hydroxypropanoate + NAD+
3-oxopropanoate + NADH + H+
-
Substrates: -
Products: -
Products: -
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
16.8
3-hydroxypropionate
-
pH 8.5, 37°C, KM-value for 3-hydroxyisobutyrate is approximately 20fold lower
additional information
additional information
-
steady-state kinetic analysis, overview
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7 - 10
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). A0A1D8PQ07_CANAL
Candida albicans (strain SC5314 / ATCC MYA-2876)
354
0
39045
TrEMBL
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
45
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
ammonium sulfate precipitation, hydrophobic interaction chromatography (Phenyl-Sepharose), anion exchange chromatography
-
native enzyme 100fold by ammonium sulfate fractionation, and hydrophobic interaction and anion exchange chromatography
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
MmsB gene, overexpression in Escherichia coli strain BL21, subcloning in strain DH5alpha
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Miyakoshi, S.; Uchiyama, H.; Someya, T.; Satoh, T.; Tabuchi, T.
Distribution of the methylcitric acid cycle and beta-oxidation pathway for propionate catabolism in fungi
Agric. Biol. Chem.
51
2381-2387
1987
Diutina catenulata, Diutina rugosa, Priceomyces haplophilus, Schwanniomyces polymorphus, Starmerella gropengiesseri
-
brenda
Den, H.; Robinson, W.G.; Coon, M.J.
Enzymatic conversion of beta-hydroxypropionate to malonic semialdehyde
J. Biol. Chem.
234
1666-1671
1959
Eremothecium ashbyi, Escherichia coli, Gallus gallus, Propionibacterium freudenreichii subsp. shermanii, Sus scrofa, Tetrahymena pyriformis
brenda
Qatibi, A.I.; Bennisse, R.; Rodrigues, C.; Reis, M.A.M.; Labat, M.
Anaerobic 1,3-propanediol dissimilation by Desulfovibrio alcoholivorans and other Desulfovibrio species
Eur. Symp. Environ. Biotechnol. , ESEB 2004, Proceedings, Oostende, Belgium, Apr. 25-28
2004
693-696
2004
no activity in Desulfovibrio carbinolicus, no activity in Desulfovibrio fructosovorans, Solidesulfovibrio alcoholivorans
-
brenda
Yao, T.; Xu, L.; Ying, H.; Huang, H.; Yan, M.
The catalytic property of 3-hydroxyisobutyrate dehydrogenase from Bacillus cereus on 3-hydroxypropionate
Appl. Biochem. Biotechnol.
160
694-703
2009
Bacillus cereus, Bacillus cereus ATCC 14579
brenda
Otzen, C.; Bardl, B.; Jacobsen, I.D.; Nett, M.; Brock, M.
Candida albicans utilizes a modified beta-oxidation pathway for the degradation of toxic propionyl-CoA
J. Biol. Chem.
289
8151-8169
2014
Candida albicans (A0A1D8PQ07), Candida albicans
brenda
EXTERNAL LINKS (specific for EC-Number 1.1.1.59)
html completed
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
About BRENDA
Social media
Help
Survey
Download
Contribution
Legal
Curated at
Member of
