EC Explorer
[browse EC tree] - [search]
EC 1.1.1.236 Details
EC number
1.1.1.236
Accepted name
tropinone reductase II
Reaction
pseudotropine + NADP+ = tropinone + NADPH + H+
Other name(s)
tropinone (ψ-tropine-forming) reductase,
pseudotropine forming tropinone reductase,
tropinone reductase (ambiguous),
TR-II
Systematic name
pseudotropine:NADP+ 3-oxidoreductase
CAS registry number
136111-61-0
Comment
This enzyme along with EC 1.1.1.206, tropine dehydrogenase, represents a branch point in tropane alkaloid metabolism [3]. Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines [3]. Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific [2].
History
created 1992, modified 2007
EC Tree
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)