Information on EC - tropinone reductase I

for references in articles please use BRENDA:EC1.1.1.206
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EC Tree
     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
       tropinone reductase I
IUBMB Comments
Also oxidizes other tropan-3alpha-ols, but not the corresponding beta-derivatives . This enzyme along with EC, tropinone reductase II, represents a branch point in tropane alkaloid metabolism . Tropine (the product of EC is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC is the first specific metabolite on the pathway to the calystegines . Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific .
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
BaTRI, dehydrogenase, tropine, DnTR1, DsTRI, More, TR-I, TR1, TRI, Tri2, tropine biosynthetic tropinone reductase, more
tropine + NADP+ = tropinone + NADPH + H+
show the reaction diagram
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