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Information on EC 1.1.1.206 - tropinone reductase I

for references in articles please use BRENDA:EC1.1.1.206

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IUBMB Comments

Also oxidizes other tropan-3α-ols, but not the corresponding β-derivatives . This enzyme along with EC 1.1.1.236, tropinone reductase II, represents a branch point in tropane alkaloid metabolism . Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines . Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific .

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
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tropine
+
NADP+
=
tropinone
+
NADPH
+
H+
+
=
+
+

Synonyms
tropinone reductase, tropinone reductase i, batri, dntr1, tropine-forming reductase, tropine dehydrogenase, wstr-i, dstri, tropinone reductase-i, tropine-forming tropinone reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
tropine + NADP+ = tropinone + NADPH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
superpathway of hyoscyamine (atropine) and scopolamine biosynthesis, tropane alkaloids biosynthesis