EC Explorer
[browse EC tree] - [search]
EC 1.1.1.86 Details
EC number
1.1.1.86
Accepted name
ketol-acid reductoisomerase (NADP+)
Reaction
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
Other name(s)
dihydroxyisovalerate dehydrogenase (isomerizing),
acetohydroxy acid isomeroreductase,
ketol acid reductoisomerase,
α-keto-β-hydroxylacyl reductoisomerase,
2-hydroxy-3-keto acid reductoisomerase,
acetohydroxy acid reductoisomerase,
acetolactate reductoisomerase,
dihydroxyisovalerate (isomerizing) dehydrogenase,
isomeroreductase,
reductoisomerase,
ketol-acid reductoisomerase,
(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
Systematic name
(2R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
CAS registry number
9075-02-9
Comment
Also catalyses the reduction of 2-ethyl-2-hydroxy-3-oxobutanoate to 2,3-dihydroxy-3-methylpentanoate. The enzyme, found in many bacteria and archaea, is specific for NADPH (cf. EC 1.1.1.382, ketol-acid reductoisomerase (NAD+) and EC 1.1.1.383, ketol-acid reductoisomerase [NAD(P)+]).
History
created 1972, modified 1976, modified 1981 (EC 1.1.1.89 created 1972, incorporated 1976), modified 2015
EC Tree
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_continue.png)
![](./taxonomy2/inc/tree/images/tree_cross.png)