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Information on EC 1.1.1.383 - ketol-acid reductoisomerase [NAD(P)+]

for references in articles please use BRENDA:EC1.1.1.383
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IUBMB Comments
The enzyme, characterized from the bacteria Hydrogenobaculum sp. and Syntrophomonas wolfei subsp. wolfei and from the archaea Metallosphaera sedula and Ignisphaera aggregans, can use both NADH and NADPH with similar efficiency [cf. EC 1.1.1.86, ketol-acid reductoisomerase (NADP+) and EC 1.1.1.382, ketol-acid reductoisomerase (NAD+)].
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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
ilvC, Shewana3_0355, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(P)+ = (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NAD(P)H + H+
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