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EC 1.17.99.10 Details
show Brenda entryEC number
1.17.99.10
Accepted name
steroid C-25 hydroxylase
Reaction
cholest-4-en-3-one + acceptor + H2O = 25-hydroxycholest-4-en-3-one + reduced acceptor
Other name(s)
s25dA1 (gene name),
s25dA1B3 (gene name),
s25dA1C3 (gene name),
cholesterol C-25 dehydrogenase,
steroid C-25 dehydrogenase
Systematic name
cholest-4-en-3-one:acceptor oxidoreductase (25-hydroxylating)
Comment
The enzyme, characterized from the bacterium Sterolibacterium denitrificans, participates in the anaerobic degradation of cholesterol. The enzyme can accept several substrates including vitamin D3. The enzyme contains a bis(guanylyl molybdopterin) cofactor, five [Fe-S] clusters, and one heme b. cf. EC 1.14.99.38, cholesterol 25-monooxygenase, an oxygen-requiring eukaryotic enzyme that catalyses a similar transformation.
History
created 2020
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.3.1 created 1961, deleted 1984 1.1.3.25 created 1986, deleted 2005 1.1.3.26 created 1989, deleted 2002 1.1.3.31 created 1992, deleted 2003 1.1.3.32 created 1999, deleted 2002 1.1.3.33 created 1999, deleted 2002 1.1.3.34 created 1999, deleted 2002 1.1.3.35 created 1999, deleted 2002 1.1.3.36 created 1999, deleted 2002
