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Information on EC 1.14.99.38 - cholesterol 25-hydroxylase

for references in articles please use BRENDA:EC1.14.99.38
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IUBMB Comments
Unlike most other sterol hydroxylases, this enzyme is not a cytochrome P-450. Instead, it uses diiron cofactors to catalyse the hydroxylation of hydrophobic substrates . The diiron cofactor can be either Fe-O-Fe or Fe-OH-Fe and is bound to the enzyme through interactions with clustered histidine or glutamate residues [4,5]. In cell cultures, this enzyme down-regulates cholesterol synthesis and the processing of sterol regulatory element binding proteins (SREBPs).
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The expected taxonomic range for this enzyme is: Tetrapoda
Synonyms
cyp3a11, ch25h, cholesterol-25-hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cholesterol + reduced acceptor + O2 = 25-hydroxycholesterol + acceptor + H2O
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PATHWAY SOURCE
PATHWAYS
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