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EC 3.6.1.58 Details

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EC number

3.6.1.58

Accepted name

8-oxo-dGDP phosphatase

Reaction

(1) 8-oxo-dGDP + H₂O = 8-oxo-dGMP + phosphate;;(2) 8-oxo-GDP + H₂O = 8-oxo-GMP + phosphate

Other name(s)

NUDT5, MTH3 (gene name), NUDT18

Systematic name

8-oxo-dGDP phosphohydrolase

Comment

The enzyme catalyses the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP thereby preventing translational errors caused by oxidative damage. The preferred in vivo substrate is not known. The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the monophosphates (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase) [1,2]. Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are hydrolysed with broad specificity. The bifunctional enzyme NUDT5 also hydrolyses ADP-ribose to AMP and D-ribose 5-phosphate (cf. EC 3.6.1.13, ADP-ribose diphosphatase) [4]. The human enzyme NUDT18 also hydrolyses 8-oxo-dADP and 2-hydroxy-dADP, the latter at a slower rate [6].

History

created 2012

EC Tree

1 Oxidoreductases

2 Transferases

3 Hydrolases

3.1 Acting on ester bonds

3.1.1 Carboxylic-ester hydrolases

3.1.2 Thioester hydrolases

3.1.3 Phosphoric-monoester hydrolases

3.1.4 Phosphoric-diester hydrolases

3.1.5 Triphosphoric-monoester hydrolases

3.1.6 Sulfuric-ester hydrolases

3.1.7 Diphosphoric-monoester hydrolases

3.1.8 Phosphoric-triester hydrolases

3.1.11 Exodeoxyribonucleases producing 5′-phosphomonoesters

3.1.12 Exodeoxyribonucleases producing 3′-phosphomonoesters

3.1.13 Exoribonucleases producing 5′-phosphomonoesters

3.1.14 Exoribonucleases producing 3'-phosphomonoesters

3.1.15 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters

3.1.16 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters

3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters

3.1.22 Endodeoxyribonucleases producing 3'-phosphomonoesters

3.1.23 Site-specific endodeoxyribonucleases: cleavage is sequence specific (deleted sub-subclass)

3.1.23.1 created 1978, deleted 1984

3.1.23.2 created 1978, deleted 1984

3.1.23.3 created 1978, deleted 1984

3.1.23.4 created 1978, deleted 1984

3.1.23.5 created 1978, deleted 1984

3.1.23.6 created 1978, deleted 1984

3.1.23.7 created 1978, deleted 1984

3.1.23.8 created 1978, deleted 1984

3.1.23.9 created 1978, deleted 1984

3.1.23.10 created 1978, deleted 1984

3.1.23.11 created 1978, deleted 1984

3.1.23.12 created 1978, modified 1982, deleted 1984

3.1.23.13 created 1978, deleted 1984

3.1.23.14 created 1978, deleted 1984

3.1.23.15 created 1978, deleted 1984

3.1.23.16 created 1978, deleted 1984

3.1.23.17 created 1978, deleted 1984

3.1.23.18 created 1978, deleted 1984

3.1.23.19 created 1978, deleted 1984

3.1.23.20 created 1978, deleted 1984

3.1.23.21 created 1978, deleted 1984

3.1.23.22 created 1978, deleted 1984

3.1.23.23 created 1978, deleted 1984

3.1.23.24 created 1978, deleted 1984

3.1.23.25 created 1978, deleted 1984

3.1.23.26 created 1978, deleted 1984

3.1.23.27 created 1978, deleted 1984

3.1.23.28 created 1978, deleted 1984

3.1.23.29 created 1978, deleted 1984

3.1.23.30 created 1978, modified 1982, deleted 1984

3.1.23.31 created 1978, deleted 1984

3.1.23.32 created 1978, modified 1982, deleted 1984

3.1.23.33 created 1978, deleted 1984

3.1.23.34 created 1978, deleted 1984

3.1.23.35 created 1978, deleted 1984

3.1.23.36 created 1978, deleted 1984

3.1.23.37 created 1978, deleted 1984

3.1.23.38 created 1978, deleted 1984

3.1.23.39 created 1978, deleted 1984

3.1.23.40 created 1978, deleted 1984

3.1.23.41 created 1978, deleted 1984

3.1.23.42 created 1978, deleted 1984

3.1.23.43 created 1978, modified 1982, deleted 1984

3.1.23.44 created 1978, deleted 1984

3.1.23.45 created 1978, modified 1982, deleted 1984

3.1.23.46 created 1982, deleted 1984

3.1.23.47 created 1982, deleted 1984

3.1.23.48 created 1982, deleted 1984

3.1.23.49 created 1982, deleted 1984

3.1.23.50 created 1982, deleted 1984

3.1.23.51 created 1982, deleted 1984

3.1.23.52 created 1982, deleted 1984

3.1.23.53 created 1982, deleted 1984

3.1.23.54 created 1982, deleted 1984

3.1.23.55 created 1982, deleted 1984

3.1.23.56 created 1982, deleted 1984

3.1.23.57 created 1982, deleted 1984

3.1.23.58 created 1982, deleted 1984

3.1.23.59 created 1982, deleted 1984

3.1.23.60 created 1982, deleted 1984

3.1.23.61 created 1982, deleted 1984

3.1.23.62 created 1982, deleted 1984

3.1.23.63 created 1982, deleted 1984

3.1.23.64 created 1982, deleted 1984

3.1.23.65 created 1982, deleted 1984

3.1.23.66 created 1982, deleted 1984

3.1.23.67 created 1982, deleted 1984

3.1.23.68 created 1982, deleted 1984

3.1.23.69 created 1982, deleted 1984

3.1.23.70 created 1982, deleted 1984

3.1.23.71 created 1982, deleted 1984

3.1.23.72 created 1982, deleted 1984

3.1.23.73 created 1982, deleted 1984

3.1.23.74 created 1982, deleted 1984

3.1.23.75 created 1982, deleted 1984

3.1.23.76 created 1982, deleted 1984

3.1.23.77 created 1982, deleted 1984

3.1.23.78 created 1982, deleted 1984

3.1.23.79 created 1982, deleted 1984

3.1.23.80 created 1982, deleted 1984

3.1.23.81 created 1982, deleted 1984

3.1.23.82 created 1982, deleted 1984

3.1.23.83 created 1982, deleted 1984

3.1.23.84 created 1982, deleted 1984

3.1.23.85 created 1982, deleted 1984

3.1.23.86 created 1982, deleted 1984

3.1.23.87 created 1982, deleted 1984

3.1.23.88 created 1982, deleted 1984

3.1.23.89 created 1982, deleted 1984

3.1.23.90 created 1982, deleted 1984

3.1.23.91 created 1982, deleted 1984

3.1.23.92 created 1982, deleted 1984

3.1.23.93 created 1982, deleted 1984

3.1.23.94 created 1982, deleted 1984

3.1.23.95 created 1982, deleted 1984

3.1.23.96 created 1982, deleted 1984

3.1.23.97 created 1982, deleted 1984

3.1.23.98 created 1982, deleted 1984

3.1.23.99 created 1982, deleted 1984

3.1.23.100 created 1982, deleted 1984

3.1.23.101 created 1982, deleted 1984

3.1.23.102 created 1982, deleted 1984

3.1.23.103 created 1982, deleted 1984

3.1.23.104 created 1982, deleted 1984

3.1.23.105 created 1982, deleted 1984

3.1.23.106 created 1982, deleted 1984

3.1.23.107 created 1982, deleted 1984

3.1.23.108 created 1982, deleted 1984

3.1.23.109 created 1982, deleted 1984

3.1.24 Site specific endodeoxyribonucleases: cleavage is not sequence specific (deleted sub-subclass)

3.1.25 Site-specific endodeoxyribonucleases that are specific for altered bases

3.1.26 Endoribonucleases producing 5'-phosphomonoesters

3.1.27 Endoribonucleases producing 3'-phosphomonoesters

3.1.30 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters

3.1.31 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters

3.2 Glycosylases

3.3 Acting on ether bonds

3.4 Acting on peptide bonds (peptidases)

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.6 Acting on acid anhydrides

3.6.1 In phosphorus-containing anhydrides

3.6.1.1 inorganic diphosphatase

3.6.1.2 trimetaphosphatase

3.6.1.3 adenosinetriphosphatase

3.6.1.4 created 1961, deleted 1965

3.6.1.5 apyrase

3.6.1.6 nucleoside diphosphate phosphatase

3.6.1.7 acylphosphatase

3.6.1.8 ATP diphosphatase

3.6.1.9 nucleotide diphosphatase

3.6.1.10 endopolyphosphatase

3.6.1.11 exopolyphosphatase

3.6.1.12 dCTP diphosphatase

3.6.1.13 ADP-ribose diphosphatase

3.6.1.14 adenosine-tetraphosphatase

3.6.1.15 nucleoside-triphosphate phosphatase

3.6.1.16 CDP-glycerol diphosphatase

3.6.1.17 bis(5′-nucleosyl)-tetraphosphatase (asymmetrical)

3.6.1.18 FAD diphosphatase

3.6.1.19 nucleoside-triphosphate diphosphatase

3.6.1.20 5′-acylphosphoadenosine hydrolase

3.6.1.21 ADP-sugar diphosphatase

3.6.1.22 NAD⁺ diphosphatase

3.6.1.23 dUTP diphosphatase

3.6.1.24 nucleoside phosphoacylhydrolase

3.6.1.25 triphosphatase

3.6.1.26 CDP-diacylglycerol diphosphatase

3.6.1.27 undecaprenyl-diphosphate phosphatase

3.6.1.28 thiamine-triphosphatase

3.6.1.29 bis(5′-adenosyl)-triphosphatase

3.6.1.30 m⁷G(5′)pppN diphosphatase

3.6.1.31 phosphoribosyl-ATP diphosphatase

3.6.1.32 created 1984, deleted 2000

3.6.1.33 created 1984, deleted 2000

3.6.1.34 created 1984, deleted 2000

3.6.1.35 created 1984, deleted 2000

3.6.1.36 created 1984, deleted 2000

3.6.1.37 created 1984, deleted 2000

3.6.1.38 created 1984, deleted 2000

3.6.1.39 thymidine-triphosphatase

3.6.1.40 guanosine-5′-triphosphate,3′-diphosphate phosphatase

3.6.1.41 bis(5′-nucleosyl)-tetraphosphatase (symmetrical)

3.6.1.42 guanosine-diphosphatase

3.6.1.43 dolichyldiphosphatase

3.6.1.44 oligosaccharide-diphosphodolichol diphosphatase

3.6.1.45 UDP-sugar diphosphatase

3.6.1.46 created 2000, deleted 2003

3.6.1.47 created 2000, deleted 2003

3.6.1.48 created 2000, deleted 200

3.6.1.49 created 2000, deleted 2003

3.6.1.50 created 2000, deleted 2003

3.6.1.51 created 2000, deleted 2003

3.6.1.52 diphosphoinositol-polyphosphate diphosphatase

3.6.1.53 Mn²⁺-dependent ADP-ribose/CDP-alcohol diphosphatase

3.6.1.54 UDP-2,3-diacylglucosamine diphosphatase

3.6.1.55 8-oxo-dGTP diphosphatase

3.6.1.56 2-hydroxy-dATP diphosphatase

3.6.1.57 UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose hydrolase

3.6.1.58 8-oxo-dGDP phosphatase

3.6.1.59 5′-(N⁷-methyl 5′-triphosphoguanosine)-[mRNA] diphosphatase

3.6.1.60 diadenosine hexaphosphate hydrolase (AMP-forming)

3.6.1.61 diadenosine hexaphosphate hydrolase (ATP-forming)

3.6.1.62 5′-(N⁷-methylguanosine 5′-triphospho)-[mRNA] hydrolase

3.6.1.63 α-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase

3.6.1.64 inosine diphosphate phosphatase

3.6.1.65 (d)CTP diphosphatase

3.6.1.66 XTP/dITP diphosphatase

3.6.1.67 dihydroneopterin triphosphate diphosphatase

3.6.1.68 geranyl diphosphate phosphohydrolase

3.6.1.69 8-oxo-(d)GTP phosphatase

3.6.1.70 guanosine-5′-diphospho-5′-[DNA] diphosphatase

3.6.1.71 adenosine-5′-diphospho-5′-[DNA] diphosphatase

3.6.1.72 DNA-3′-diphospho-5′-guanosine diphosphatase

3.6.1.73 inosine/xanthosine triphosphatase

3.6.1.74 mRNA 5′-phosphatase

3.6.1.75 diacylglycerol diphosphate phosphatase

3.6.2 In sulfonyl-containing anhydrides

3.6.3 Acting on acid anhydrides to catalyse transmembrane movement of substances

3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement

3.6.5 Acting on GTP to facilitate cellular and subcellular movement

3.7 Acting on carbon-carbon bonds

3.8 Acting on halide bonds

3.9 Acting on phosphorus-nitrogen bonds

3.10 Acting on sulfur-nitrogen bonds

3.11 Acting on carbon-phosphorus bonds

3.12 Acting on sulfur-sulfur bonds

3.13 Acting on carbon-sulfur bonds