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EC 3.1.3.66 Details
EC number
3.1.3.66
Accepted name
phosphatidylinositol-3,4-bisphosphate 4-phosphatase
Reaction
1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate
Other name(s)
inositol-3,4-bisphosphate 4-phosphatase,
D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase,
phosphoinositide 4-phosphatase,
inositol polyphosphate 4-phosphatase,
inositol polyphosphate 4-phosphatase type II
Systematic name
1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase
CAS registry number
123644-80-4
Comment
Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P.
History
created 1992, modified 2002
EC Tree
3.1.3.30 created 1972, deleted 1992
3.1.3.61 created 1992, deleted 2002
3.1.3.65 created 1992, deleted 2002