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EC 3.1.3.4 Details
EC number
3.1.3.4
Accepted name
phosphatidate phosphatase
Reaction
a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate
Other name(s)
phosphatic acid phosphatase, acid phosphatidyl phosphatase, phosphatic acid phosphohydrolase, PAP, Lipin
Systematic name
diacylglycerol-3-phosphate phosphohydrolase
CAS registry number
9025-77-8
Comment
This enzyme catalyses the Mg2+-dependent dephosphorylation of a 1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol (DAG), the substrate for de novo lipid synthesis via the Kennedy pathway and for the synthesis of triacylglycerol. In lipid signalling, the enzyme generates a pool of DAG to be used for protein kinase C activation. The mammalian enzymes are known as lipins.
History
created 1961, modified 2010
EC Tree
3.1.3.30 created 1972, deleted 1992
3.1.3.61 created 1992, deleted 2002
3.1.3.65 created 1992, deleted 2002