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EC 1.14.14.17 Details
show Brenda entryEC number
1.14.14.17
Accepted name
squalene monooxygenase
Reaction
squalene + [reduced NADPH—hemoprotein reductase] + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
squalene epoxidase,
squalene-2,3-epoxide cyclase,
squalene 2,3-oxidocyclase,
squalene hydroxylase,
squalene oxydocyclase,
squalene-2,3-epoxidase
Systematic name
squalene,NADPH—hemoprotein:oxygen oxidoreductase (2,3-epoxidizing)
CAS registry number
9029-62-3
Comment
A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7, lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor is EC 1.6.2.4, NADPH—hemoprotein reductase [5,7].
History
created 1961 as EC 1.99.1.13, transferred 1965 to EC 1.14.1.3, part transferred 1972 to EC 1.14.99.7, transferred 2011 to EC 1.14.13.132, transferred 2015 to EC 1.14.14.17
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
