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EC 1.14.14.132 Details
show Brenda entryEC number
1.14.14.132
Accepted name
(–)-4′-demethyl-deoxypodophyllotoxin 4-hydroxylase
Reaction
(–)-4′-demethyldeoxypodophyllotoxin + [reduced NADPH—hemoprotein reductase] + O2 = (–)-4′-demethylepipodophyllotoxin + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
CYP82D61 (gene name)
Systematic name
(–)-deoxypodophyllotoxin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
Comment
A cytochrome P-450 (heme-thiolate) protein characterized from the plant Sinopodophyllum hexandrum. The enzyme produces the direct precursor to etoposide, a potent anticancer drug. It can also act on (–)-deoxypodophyllotoxin with lower efficiency.
History
created 2016 as EC 1.14.13.214, transferred 2018 to EC 1.14.14.132
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
