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EC 1.1.99.27 Details
show Brenda entryEC number
1.1.99.27
Accepted name
(R)-pantolactone dehydrogenase (flavin)
Reaction
(R)-pantolactone + acceptor = 2-dehydropantolactone + reduced acceptor
Other name(s)
2-dehydropantolactone reductase (flavin),
2-dehydropantoyl-lactone reductase (flavin),
(R)-pantoyllactone dehydrogenase (flavin)
Systematic name
(R)-pantolactone:acceptor oxidoreductase (flavin-containing)
CAS registry number
140879-14-7
Comment
High specificity for (R)-pantolactone. Phenazine methosulfate (PMS) can act as acceptor. The enzyme has been studied in the bacterium Nocardia asteroides and shown to be membrane-bound and induced by 1,2-propanediol. The FMN cofactor is non-covalently bound.
History
created 1999
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.3.1 created 1961, deleted 1984 1.1.3.25 created 1986, deleted 2005 1.1.3.26 created 1989, deleted 2002 1.1.3.31 created 1992, deleted 2003 1.1.3.32 created 1999, deleted 2002 1.1.3.33 created 1999, deleted 2002 1.1.3.34 created 1999, deleted 2002 1.1.3.35 created 1999, deleted 2002 1.1.3.36 created 1999, deleted 2002 1.1.99.15 created 1978, deleted 1980 1.1.99.17 created 1982, deleted 2003
