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EC 1.5.5.2 Details
show Brenda entryEC number
1.5.5.2
Accepted name
proline dehydrogenase
Reaction
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol
Other name(s)
L-proline dehydrogenase,
L-proline:(acceptor) oxidoreductase
Systematic name
L-proline:quinone oxidoreductase
CAS registry number
9050-70-8
Comment
A flavoprotein (FAD). The electrons from L-proline are transferred to the FAD cofactor, and from there to a quinone acceptor [3]. In many organisms, ranging from bacteria to mammals, proline is oxidized to glutamate in a two-step process involving this enzyme and EC 1.2.1.88, L-glutamate γ-semialdehyde dehydrogenase. Both activities are carried out by the same enzyme in enterobacteria.
History
created 1980 as EC 1.5.99.8, transferred 2013 to EC 1.5.5.2
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.99.15 created 1978, deleted 1980 1.1.99.17 created 1982, deleted 2003
