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EC 2.3.1.257 Details
EC number
2.3.1.257
Accepted name
N-terminal L-serine Nα-acetyltransferase NatD
Reaction
(1) acetyl-CoA + an N-terminal-L-seryl-[histone H4] = an N-terminal-Nα-acetyl-L-seryl-[histone H4] + CoA;;(2) acetyl-CoA + an N-terminal-L-seryl-[histone H2A] = an N-terminal-Nα-acetyl-L-seryl-[histone H2A] + CoA
Other name(s)
NAA40 (gene name)
Systematic name
acetyl-CoA:N-terminal-L-seryl-[histone 4/2A] L-serine Nα-acetyltransferase
Comment
N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free α-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic. NatD is found in all eukaryotic organisms, and acetylates solely the serine residue at the N-terminus of histones H2A or H4. Efficient recognition and acetylation by NatD requires at least the first 30 to 50 highly conserved amino acid residues of the histone N terminus.
History
created 1989 as EC 2.3.1.88, part transferred 2016 to EC 2.3.1.257
EC Tree
1.1.99.15 created 1978, deleted 1980
1.1.99.17 created 1982, deleted 2003