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Information on EC 2.3.1.257 - N-terminal L-serine Nalpha-acetyltransferase NatD

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IUBMB Comments
N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic. NatD is found in all eukaryotic organisms, and acetylates solely the serine residue at the N-terminus of histones H2A or H4. Efficient recognition and acetylation by NatD requires at least the first 30 to 50 highly conserved amino acid residues of the histone N terminus.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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an N-terminal-L-seryl-[histone H4]
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an N-terminal-Nalpha-acetyl-L-seryl-[histone H4]
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an N-terminal-L-seryl-[histone H2A]
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an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A]
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Synonyms
patt1, naa40, naa40p, hnaa40p/hnatd, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + an N-terminal-L-seryl-[histone H2A] = an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA
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(2)
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acetyl-CoA + an N-terminal-L-seryl-[histone H4] = an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA
show the reaction diagram
(1)
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