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EC 1.1.99.7 Details
EC number
1.1.99.7
Accepted name
lactate—malate transhydrogenase
Reaction
(S)-lactate + oxaloacetate = pyruvate + malate
Other name(s)
malate-lactate transhydrogenase
Systematic name
(S)-lactate:oxaloacetate oxidoreductase
CAS registry number
9077-15-0
Comment
Catalyses hydrogen transfer from C3 or C4 (S)-2-hydroxy acids to 2-oxo acids. It contains tightly bound nicotinamide nucleotide in its active centre. This prosthetic group cannot be removed without denaturation of the protein.
History
created 1972
EC Tree
1.1.99.15 created 1978, deleted 1980
1.1.99.17 created 1982, deleted 2003