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EC 3.6.1.62 Details
EC number
3.6.1.62
Accepted name
5′-(N7-methylguanosine 5′-triphospho)-[mRNA] hydrolase
Reaction
a 5′-(N7-methylguanosine 5′-triphospho)-[mRNA] + H2O = N7-methylguanosine 5′-diphosphate + a 5′-phospho-[mRNA]
Other name(s)
Dcp2, NUDT16, D10 protein, D9 protein, D10 decapping enzyme, decapping enzyme, m7GpppN-mRNA hydrolase, m7GpppN-mRNA m7GDP phosphohydrolase
Systematic name
5′-(N7-methylguanosine 5′-triphospho)-[mRNA] N7-methylguanosine-5′-diphosphate phosphohydrolase
Comment
Decapping of mRNA is a critical step in eukaryotic mRNA turnover. The enzyme is unable to cleave a free cap structure (m7GpppG) [3]. The enzyme from Vaccinia virus is synergistically activated in the presence of Mg2+ and Mn2+ [5].
History
created 2012, modified 2013
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.2 Glycosylases
3.3 Acting on ether bonds
3.3.1 Thioether and trialkylsulfonium hydrolases (deleted sub-subclass)
3.3.2 Ether hydrolases
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.6.1 In phosphorus-containing anhydrides
3.6.1.1 inorganic diphosphatase
3.6.1.2 trimetaphosphatase
3.6.1.3 adenosinetriphosphatase
3.6.1.4 created 1961, deleted 1965
3.6.1.5 apyrase
3.6.1.6 nucleoside diphosphate phosphatase
3.6.1.7 acylphosphatase
3.6.1.8 ATP diphosphatase
3.6.1.9 nucleotide diphosphatase
3.6.1.10 endopolyphosphatase
3.6.1.11 exopolyphosphatase
3.6.1.12 dCTP diphosphatase
3.6.1.13 ADP-ribose diphosphatase
3.6.1.14 adenosine-tetraphosphatase
3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.16 CDP-glycerol diphosphatase
3.6.1.17 bis(5′-nucleosyl)-tetraphosphatase (asymmetrical)
3.6.1.18 FAD diphosphatase
3.6.1.19 nucleoside-triphosphate diphosphatase
3.6.1.20 5′-acylphosphoadenosine hydrolase
3.6.1.21 ADP-sugar diphosphatase
3.6.1.22 NAD+ diphosphatase
3.6.1.23 dUTP diphosphatase
3.6.1.24 nucleoside phosphoacylhydrolase
3.6.1.25 triphosphatase
3.6.1.26 CDP-diacylglycerol diphosphatase
3.6.1.27 undecaprenyl-diphosphate phosphatase
3.6.1.28 thiamine-triphosphatase
3.6.1.29 bis(5′-adenosyl)-triphosphatase
3.6.1.30 m7G(5′)pppN diphosphatase
3.6.1.31 phosphoribosyl-ATP diphosphatase
3.6.1.32 created 1984, deleted 2000
3.6.1.33 created 1984, deleted 2000
3.6.1.34 created 1984, deleted 2000
3.6.1.35 created 1984, deleted 2000
3.6.1.36 created 1984, deleted 2000
3.6.1.37 created 1984, deleted 2000
3.6.1.38 created 1984, deleted 2000
3.6.1.39 thymidine-triphosphatase
3.6.1.40 guanosine-5′-triphosphate,3′-diphosphate phosphatase
3.6.1.41 bis(5′-nucleosyl)-tetraphosphatase (symmetrical)
3.6.1.42 guanosine-diphosphatase
3.6.1.43 dolichyldiphosphatase
3.6.1.44 oligosaccharide-diphosphodolichol diphosphatase
3.6.1.45 UDP-sugar diphosphatase
3.6.1.46 created 2000, deleted 2003
3.6.1.47 created 2000, deleted 2003
3.6.1.48 created 2000, deleted 200
3.6.1.49 created 2000, deleted 2003
3.6.1.50 created 2000, deleted 2003
3.6.1.51 created 2000, deleted 2003
3.6.1.52 diphosphoinositol-polyphosphate diphosphatase
3.6.1.53 Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
3.6.1.54 UDP-2,3-diacylglucosamine diphosphatase
3.6.1.55 8-oxo-dGTP diphosphatase
3.6.1.56 2-hydroxy-dATP diphosphatase
3.6.1.57 UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose hydrolase
3.6.1.58 8-oxo-dGDP phosphatase
3.6.1.59 5′-(N7-methyl 5′-triphosphoguanosine)-[mRNA] diphosphatase
3.6.1.60 diadenosine hexaphosphate hydrolase (AMP-forming)
3.6.1.61 diadenosine hexaphosphate hydrolase (ATP-forming)
3.6.1.62 5′-(N7-methylguanosine 5′-triphospho)-[mRNA] hydrolase
3.6.1.63 α-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase
3.6.1.64 inosine diphosphate phosphatase
3.6.1.65 (d)CTP diphosphatase
3.6.1.66 XTP/dITP diphosphatase
3.6.1.67 dihydroneopterin triphosphate diphosphatase
3.6.1.68 geranyl diphosphate phosphohydrolase
3.6.1.69 8-oxo-(d)GTP phosphatase
3.6.1.70 guanosine-5′-diphospho-5′-[DNA] diphosphatase
3.6.1.71 adenosine-5′-diphospho-5′-[DNA] diphosphatase
3.6.1.72 DNA-3′-diphospho-5′-guanosine diphosphatase
3.6.1.73 inosine/xanthosine triphosphatase
3.6.1.74 mRNA 5′-phosphatase
3.6.1.75 diacylglycerol diphosphate phosphatase
3.6.2 In sulfonyl-containing anhydrides
3.6.3 Acting on acid anhydrides to catalyse transmembrane movement of substances
3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement
3.6.5 Acting on GTP to facilitate cellular and subcellular movement
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases