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EC 3.1.4.58 Details
show Brenda entryEC number
3.1.4.58
Accepted name
RNA 2′,3′-cyclic 3′-phosphodiesterase
Reaction
(ribonucleotide)n-2′,3′-cyclic phosphate + H2O = (ribonucleotide)n-2′-phosphate
Other name(s)
thpR (gene name),
ligT (gene name)
Systematic name
(ribonucleotide)n-2′,3′-cyclic phosphate 3′-nucleotidohydrolase
Comment
The enzyme hydrolyses RNA 2′,3′-cyclic phosphodiester to an RNA 2′-phosphomonoester. In vitro the enzyme can also ligate tRNA molecules with 2′,3′-cyclic phosphate to tRNA with 5′-hydroxyl termini, forming a 2′-5′ phosphodiester linkage. However, the ligase activity is unlikely to be relevant in vivo.
History
created 2017
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1 Oxidoreductases
3 Hydrolases
3.1.1.9 created 1961, deleted 1972 3.1.1.12 created 1961, deleted 1972 3.1.1.16 created 1961, deleted 1972 3.1.1.18 created 1961, deleted 1982 3.1.1.62 created 1989, deleted 1992 3.1.1.69 created 1992, deleted 2002 3.1.4.5 created 1961, deleted 1978 3.1.4.6 created 1961, deleted 1978 3.1.4.7 created 1961, deleted 1978 3.1.4.9 created 1965, deleted 1978 3.1.4.10 created 1972, modified 1976, deleted 2002 3.1.4.18 created 1972, deleted 1978 3.1.4.19 created 1972, deleted 1978 3.1.4.20 created 1972, deleted 1978 3.1.4.21 created 1972, deleted 1978 3.1.4.22 created 1972, deleted 1978 3.1.4.23 created 1972, deleted 1978 3.1.4.24 created 1972, deleted 1978 3.1.4.25 created 1972, deleted 1978 3.1.4.26 created 1972, deleted 1978 3.1.4.27 created 1972, deleted 1978 3.1.4.28 created 1972, deleted 1978 3.1.4.29 created 1972, deleted 1978 3.1.4.30 created 1972, deleted 1978 3.1.4.31 created 1972, deleted 1978 3.1.4.32 created 1972, deleted 1978 3.1.4.33 created 1972, deleted 1978 3.1.4.34 created 1972, deleted 1978 3.1.4.36 created 1976, deleted 2002 3.1.4.47 created 1989, deleted 2002
