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6.2.1.4: succinate-CoA ligase (GDP-forming)

This is an abbreviated version!
For detailed information about succinate-CoA ligase (GDP-forming), go to the full flat file.

Word Map on EC 6.2.1.4

Reaction

GTP
+
succinate
 +
CoA
=
GDP
 +
phosphate
 +
succinyl-CoA

Synonyms

ATP-specific SCS, G-SCS, G-STK, G-SUCL, GDP-forming SUCL, GTP-dependent succinate:CoA ligase, GTP-forming SUCL, GTP-specific succinate:CoA ligase, GTP-specific succinyl-CoA synthetase, GTP-specific SUCL, GTPSCS, SCS, SCS-alpha, SCS-beta, SCS-betaG, ScsA, SCSalpha, SucCDAm, Succinate thiokinase, succinate-CoA ligase, Succinic thiokinase, Succinyl CoA synthetase, Succinyl coenzyme A synthetase, Succinyl coenzyme A synthetase (GDP-forming), Succinyl coenzyme A synthetase (guanosine diphosphate-forming), succinyl-CoA synthase, Succinyl-CoA synthetase, Succinyl-CoA synthetase (GDP-forming), succinyl-CoA synthetase subunit beta, succinyl-coenzyme A synthetase, SUCL, SUCLG1, SUCLG2, Synthetase, succinyl coenzyme A (guanosine diphosphate-forming)

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.4 succinate-CoA ligase (GDP-forming)

Cloned

Cloned on EC 6.2.1.4 - succinate-CoA ligase (GDP-forming)

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
alpha-subunit, the deduced amino acid sequence shows 75% identity to that of rat liver, which represents a GTP-utilizing form of SCS, and 62% identity to the Escherichia coli protein, which is an ATP-utilizing form
-
beta-subunit
-
crystallization of the phosphorylated and of the dephosphorylated enzyme form, refined to 2.1 A resolution
-
cytoplasmic precursor of the alpha-subunit, amino acid sequence of the alpha subunit shows an extraordinary degree of homology to the alpha subunbit of Escherichia coli succinyl-CoA synthetase, with more than 70% of the residues identical
-
expressed in Escherichia coli
-
expressed in Escherichia coli BL21(DE3) cells
gene scsA, DNA and amino acid sequence determination and analysis, quantitative expression analysis in in tachyzoites and in vitro bradyzoites, overview
gene sucCD, DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain BL21(DE3)/pLysS
gene sucCD, expression in Escherichia coli strain BL21(DE3)/pLysS
gene SUCLA2, DNA and amino acid sequence determination and analysis, semi quantitative RT-PCR expression analysis
-
two mRNA transcripts arise from a single gene and are generated by mutually exclusive splicing