6.1.1.9: valine-tRNA ligase
This is an abbreviated version!
For detailed information about valine-tRNA ligase, go to the full flat file.
Word Map on EC 6.1.1.9
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6.1.1.9
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synthetases
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aminoacylation
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aminoacyl-trna
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valylation
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isoleucyl-trna
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anticodon
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ilers
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turnip
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noncognate
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leucyl-trna
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mischarged
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trna-like
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isoleucyl
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misacylated
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misactivated
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post-transfer
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l-shaped
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aarss
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phenylalanyl-trna
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threonylation
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trnaile
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cysrs
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atp-ppi
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medicine
- 6.1.1.9
- synthetases
- aminoacylation
- aminoacyl-trna
-
valylation
-
isoleucyl-trna
-
anticodon
- ilers
-
turnip
-
noncognate
- leucyl-trna
-
mischarged
-
trna-like
-
isoleucyl
-
misacylated
-
misactivated
-
post-transfer
-
l-shaped
-
aarss
- phenylalanyl-trna
-
threonylation
- trnaile
- cysrs
-
atp-ppi
- medicine
Reaction
Synonyms
G7a, glp-4, mitochondrial valyl tRNA synthetase, More, MTTV, Os03g0694900, OsValRS2, Synthetase, valyl-transfer ribonucleate, Val-tRNA synthetase, Valine transfer ribonucleate ligase, Valine translase, Valine--tRNA ligase, ValRS, ValRS1, ValRS2, valS, valyl aminoacyl tRNA synthetase, Valyl transfer ribonucleic acid synthetase, Valyl-transfer ribonucleate synthetase, Valyl-transfer RNA synthetase, Valyl-tRNA ligase, Valyl-tRNA synthetase, valyl-tRNAsynthetase, VARS, VARS-2, Vas1, Vas2, white panicle1
ECTree
Advanced search results
Turnover Number
Turnover Number on EC 6.1.1.9 - valine-tRNA ligase
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50
ATP
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ATP-diphosphate exchange reaction, His-tagged wild-type enzyme, pH 7.5, 25°C
57
ATP
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ATP-diphosphate exchange reaction, His-tagged K277A mutant enzyme, pH 7.5, 25°C
0.064
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aminoacylation reaction, His-tagged K277A mutant enzyme, pH 7.5, 25°C
0.68
L-valine
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with mutant tRNAVal with 3'-terminal 2-aminopurine base analogue, pH 7.5, 37°C
0.99
L-valine
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with mutant tRNAVal with 3'-terminal isoguanosine base analogue, pH 7.5, 37°C
1.06
L-valine
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with mutant tRNAVal with 3'-terminal inosine base analogue, pH 7.5, 37°C
1.5
L-valine
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aminoacylation reaction, His-tagged wild-type enzyme, pH 7.5, 25°C
6.08
L-valine
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with mutant tRNAVal with 3'-terminal 2-aminopurine base analogue, pH 7.5, 37°C
6.08
L-valine
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with mutant tRNAVal with 3'-terminal inosine base analogue, pH 7.5, 37°C
6.08
L-valine
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with mutant tRNAVal with 3'-terminal isoguanosine base analogue, pH 7.5, 37°C
14.4
L-valine
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with mutant tRNAVal with 3'-terminal purine riboside base analogue, pH 7.5, 37°C
1.5
tRNAVal
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aminoacylation reaction with L-valine, K277A mutant enzyme, pH 7.5, 25°C
1.7
tRNAVal
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aminoacylation reaction with L-valine, wild-type enzyme, pH 7.5, 25°C
50
tRNAVal
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ATP-diphosphate exchange reaction, K277A mutant enzyme, pH 7.5, 25°C
51
tRNAVal
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ATP-diphosphate exchange reaction, wild-type enzyme, pH 7.5, 25°C
additional information
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kcat for tRNAVal mutants, loss of the electrostatically interactions between the coiled-coil domain of the enzyme and base A20 and tertiary bas pair G19.C56 increases the kcat for aminoacylation by 19fold
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additional information
additional information
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rate of hydrolysis of Thr-tRNAVal and Val-tRNAVal by wild-type and mutant enzyme, incorporation of amino acids valine and threonine into the enzyme
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