4.4.1.13: cysteine-S-conjugate beta-lyase

This is an abbreviated version!
For detailed information about cysteine-S-conjugate beta-lyase, go to the full flat file.

Reaction

Synonyms

AAR, beta-cystathionase, beta-lyase, C-DES, C-S lyase, CBL, CBL/ALR, CBS, CCBL2, Ctl1, Ctl2, cystathionine beta-lyase, cystathionine beta/gamma-lyase, cystathionine lyase, cysteine conjugate beta-lyase, cysteine conjugate. beta.-lyase, cysteine lyase, cysteine S-conjugate beta-lyase, cysteine-S-conjugate beta-lyase, cystine C-S lyase, cystine lyase, EC 4.4.1.6, EC 4.4.1.8, EcCBL, glutamine transaminase K, glutamine transaminase K/cysteine conjugate beta-lyase, GTK, Irc7p, KAT, KAT III, KYAT3, kynurenine aminotransferase, kynurenine-oxoglutarate transaminase 3, L-cystine C-S lyase, LACBS_00576, lyase, cystathionine beta-, lyase, cysteine conjugate.beta., MalY, MetC, More, Mp CBL, ORF5, osteotoxin, patB, PatB protein, Str3p, TmCBL, TTHA1620, wMelCBL

ECTree

     4 Lyases

         4.4 Carbon-sulfur lyases

             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

                4.4.1.13 cysteine-S-conjugate beta-lyase

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Results	in table
8	Activating Compound
11220	AA Sequence
11	Application
2	CAS Registry Number
36	Cloned(Commentary)
71	Cofactor
6	Crystallization (Commentary)
99	Disease/ Diagnostics
4	Expression
44	General Information
11	General Stability
30	IC50 Value
148	Inhibitors
41	kcat/KM [mM/s]
11	Ki Value [mM]
137	KM Value [mM]
40	Localization
2	Metals/Ions
56	Molecular Weight [Da]
48	Natural Substrates/ Products (Substrates)
167	Organism
20	Pathway
32	PDB ID
43	pH Optimum
13	pH Range
5	pH Stability
2	pI Value
2	Posttranslational Modification
42	Protein Variants
59	Purification (Commentary)
11	Reaction
19	Reaction Type
161	Reference
1	Renatured (Commentary)
90	Source Tissue
37	Specific Activity [micromol/min/mg]
18	Storage Stability
421	Substrates and Products (Substrate)
47	Subunits
127	Synonyms
1	Systematic Name
25	Temperature Optimum [°C]
2	Temperature Range [°C]
20	Temperature Stability [°C]
41	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.4.1.13 - cysteine-S-conjugate beta-lyase

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SYSTEMATIC NAME

IUBMB Comments

L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)

A pyridoxal-phosphate protein. The enzyme is promiscuous regarding the moiety conjugated to L-cysteine, and can accept both aliphatic and aromatic substitutions. The enzyme cleaves a carbon-sulfur bond, releasing a thiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. While bacteria and plants have dedicated enzymes, all of the animal enzymes discovered thus far are bifunctional, most of which also act as aminotransferases.