4.1.1.45: aminocarboxymuconate-semialdehyde decarboxylase

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For detailed information about aminocarboxymuconate-semialdehyde decarboxylase, go to the full flat file.

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Synonyms

2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, 3-(3-oxoprop-2-enyl)-2-aminobut-2-endioate carboxy-lyase, ACMS decarboxylase, ACMSD, ACMSD I, ACMSDase, alpha-amino beta-carboxymuconate epsilon-semialdehyde decarboxylase, alpha-Amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase, alpha-Amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase, alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, alpha-amino-beta-carboxymuconic-epsilon-semialdehyde decarboxylase, Amino-carboxymuconate-semialdehyde decarboxylase, Decarboxylase, aminocarboxymuconate semialdehyde, hACMSD, NbaD enzyme, Picolinic acid carboxylase, Picolinic acid decarboxylase, picolinic carboxylase, Picolinic decarboxylase

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.45 aminocarboxymuconate-semialdehyde decarboxylase

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Results	in table
2	Activating Compound
1722	AA Sequence
10	Application
1	CAS Registry Number
17	Cloned(Commentary)
6	Crystallization (Commentary)
29	Disease/ Diagnostics
3	Expression
3	General Information
1	IC50 Value
50	Inhibitors
1	Ki Value [mM]
21	KM Value [mM]
25	Metals/Ions
11	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
47	Organism
7	Pathway
33	PDB ID
7	pH Optimum
1	pH Range
2	pH Stability
14	Protein Variants
15	Purification (Commentary)
2	Reaction
2	Reaction Type
46	Reference
24	Source Tissue
17	Specific Activity [micromol/min/mg]
6	Storage Stability
70	Substrates and Products (Substrate)
5	Subunits
75	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
16	Turnover Number [1/s]

Disease

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Disease on EC 4.1.1.45 - aminocarboxymuconate-semialdehyde decarboxylase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

aminocarboxymuconate-semialdehyde decarboxylase deficiency

The ACMSD gene, involved in tryptophan metabolism, is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism.

23955123

Brain Neoplasms

The kynurenine pathway in brain tumor pathogenesis.

23144293

Carcinoma, Hepatocellular

Purification and molecular cloning of rat 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase.

11802786

Diabetes Mellitus, Experimental

Effect of dietary linoleic acid on the tryptophan-niacin metabolism in streptozotocin diabetic rats.

7671148

Epilepsies, Myoclonic

The ACMSD gene, involved in tryptophan metabolism, is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism.

23955123

Malaria, Cerebral

The crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis.

19843166

Nervous System Diseases

Genome-wide association study for type 2 diabetes in indians identifies a new susceptibility locus at 2q21.

23209189

Nervous System Diseases

The crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis.

19843166

Neurodegenerative Diseases

Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements for NAD+ Synthesis.

30380424

Parkinson Disease

A Novel p.Glu298Lys Mutation in the ACMSD Gene in Sporadic Parkinson's Disease.

28671144

Parkinsonian Disorders

Is the Enzyme ACMSD a Novel Therapeutic Target in Parkinson's Disease?

29103054

Parkinsonian Disorders

The ACMSD gene, involved in tryptophan metabolism, is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism.

23955123

Pellagra

Acrodermatitis enteropathica and the relation to pellagra.

7289905

Renal Insufficiency

Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency.

10966936

Seizures

The ACMSD gene, involved in tryptophan metabolism, is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism.

23955123

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