4.1.1.45: aminocarboxymuconate-semialdehyde decarboxylase

This is an abbreviated version!
For detailed information about aminocarboxymuconate-semialdehyde decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.45

Reaction

2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
=
2-aminomuconate semialdehyde
+
CO2

Synonyms

Decarboxylase, aminocarboxymuconate semialdehyde, Picolinic acid carboxylase, Picolinic acid decarboxylase, alpha-Amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase, alpha-Amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase, Amino-carboxymuconate-semialdehyde decarboxylase, Picolinic decarboxylase, ACMSD, 3-(3-oxoprop-2-enyl)-2-aminobut-2-endioate carboxy-lyase, alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, ACMSDase, 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, NbaD enzyme, ACMSD I, ACMS decarboxylase, 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, alpha-amino-beta-carboxymuconic-epsilon-semialdehyde decarboxylase, alpha-amino beta-carboxymuconate epsilon-semialdehyde decarboxylase, hACMSD, picolinic carboxylase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.45 aminocarboxymuconate-semialdehyde decarboxylase

Inhibitors

Inhibitors on EC 4.1.1.45 - aminocarboxymuconate-semialdehyde decarboxylase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,3-dihydroxyacetonephosphate
-
2-hydroxymuconate 6-semialdehyde
-
-
3-[[[5-cyano-1,6-dihydro-6-oxo-4-(2-thienyl)-2-pyrimidinyl]thio]methyl]phenylacetic acid
potent and selective inhibitor. Treatment of primary hepatocytes significantly increases intracellular NAD+ levels. compound exhibits good solubility with low permeability of cells and no inhibition of cytochrome P450s
Cd2+
-
0.5 mM, reduces the enzymatic activity to 25%
Cr3+
-
0.5 mM, reduces the enzymatic activity to 35%
CuSO4
-
-
diethyldicarbonate
-
-
EDTA
-
-
eicosapentaenoic acid
-
ACMSD mRNA levels in primary hepatocytes are decreased by the incubation with high concentrations of eicosapentaenoic acid
Fe3+
-
0.1 mM, reduces the enzymatic activity to 15%
HgCl2
-
-
iodoacetamide
-
-
Kynurenic acid
-
1 mM, 59% residual activity
linoleic acid
-
ACMSD mRNA levels in primary hepatocytes are decreased by the incubation with high concentrations of linoleic acid
mono (2-ethyl hexyl) phthalate
-
90% inhibition of ACMSD activity in the presence of 3 mmol/l mono (2-ethyl hexyl) phthalate, inhibition is reversible
mono (2-ethylhexyl) phthalate
mono-n-butyl phthalate
mono-n-hexyl phthalate
Monoiodoacetic acid
-
-
N-Acetylimidazole
-
-
NaF
-
-
NEM
-
-
p-chloromercuribenzoate
p-chloromercuribenzoic acid
-
-
peroxisome proliferator-activated receptor alpha
-
gene expression is downregulated by activation of peroxisome proliferator-activated receptor alpha
-
Picolinic acid
-
1 mM, 47% residual activity
pyridine-2,6-dicarboxylic acid
-
competitive
quinolinic acid
-
1 mM, 61% residual activity
WY-14,643
-
ACMSD mRNA levels in primary hepatocytes are decreased by the incubation with high concentrations of WY-14,643
Zn2+
-
0.1 mM, reduces the enzymatic activity to 6%
[4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid
-
suppresses ACMSD activity
additional information
-