3.4.21.46: complement factor D

This is an abbreviated version!
For detailed information about complement factor D, go to the full flat file.

Reaction

selective cleavage of Arg-/-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor =

Synonyms

28 kDa protein, adipocyte, Adipsin, alternative complement pathway component Factor D, C3 convertase activator, C3 proactivator convertase, CFD, complement factor D/adipsin and kallikrein-like serine protease, convertase, C3 proactivator, Df, Df protein, endogenous vascular elastase, esterase, properdin factor D, factor D, factor D (complement), fD, PDGF-D, platelet-derived growth factor D, PoDAK, vascular endothelial growth factor, vascular endothelial growth factor D, VEGF-D

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.46 complement factor D

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Results	in table
4	Activating Compound
169	AA Sequence
8	Application
1	CAS Registry Number
14	Cloned(Commentary)
11	Crystallization (Commentary)
77827	Disease/ Diagnostics
9	Expression
21	General Information
1	General Stability
41	IC50 Value
53	Inhibitors
8	KM Value [mM]
3	Localization
1	Metals/Ions
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
189	Organism
103	PDB ID
3	pI Value
4	Posttranslational Modification
28	Protein Variants
18	Purification (Commentary)
1	Reaction
1	Reaction Type
50	Reference
77	Source Tissue
11	Specific Activity [micromol/min/mg]
2	Storage Stability
41	Substrates and Products (Substrate)
7	Subunits
49	Synonyms
8	Turnover Number [1/s]

Cloned

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Cloned on EC 3.4.21.46 - complement factor D

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Homo sapiens

-

36592

baculoviral VEGF-D or adenoviral VEGF-D expressed in the rabbit eye. VEGF-D expression shows a similar pattern in the retina and retinal pigment epithelium layer after baculoviral and adenoviral transduction. At 6 days after gene transfer, both viruses show dose-dependent increase in the expression of human VEGF-D in the vitreous humour

Homo sapiens

-

699302

Df-deficient mice show protection against the development of proliferative renal disease

Mus musculus

-

670101

expressed in breast cancer cell lines MDA-MB-468 and MCF-7 cells

Homo sapiens

-

707940

expressed in Escherichia coli

Homo sapiens

P00746

754401

expressed in Escherichia coli BL21(DE3) cells

Oplegnathus fasciatus

-

753602

expressed in Escherichia coli Rosetta (DE3) cells

Megalobrama amblycephala

-

753616

expressed in HEK-293T cells

Mus musculus

Q3UP47

755129

expressed in HEK293-E cells

Homo sapiens

-

718398

expressed in HeLa S3 cells

Homo sapiens

-

754127

factor D gene expression is upregulated by western diet

Mus musculus

P03953

670498

gastric cells transiently transfected with the pGL3-based vegf-D reporter gene construct vegf-D(-2011/+110), which comprises nucleotides -2011/+110 of the human vegf-D gene

Homo sapiens

-

697096

mutants transiently transfected into 293T cells. The native VEGF-DDELTANDELTAC and mutants expressed in a larger scale in insect cells using BVboostFG baculovirus expression system

Homo sapiens

O43915

698902

transient expression of wild-type and mutant enzymes in HEK-293-E cells from pUPE.05.05 expression vectors, the recombinant proteins are secreted

Homo sapiens

P00746

731071