3.4.21.46: complement factor D

This is an abbreviated version!
For detailed information about complement factor D, go to the full flat file.

Reaction

selective cleavage of Arg-/-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor =

Synonyms

28 kDa protein, adipocyte, Adipsin, alternative complement pathway component Factor D, C3 convertase activator, C3 proactivator convertase, CFD, complement factor D/adipsin and kallikrein-like serine protease, convertase, C3 proactivator, Df, Df protein, endogenous vascular elastase, esterase, properdin factor D, factor D, factor D (complement), fD, PDGF-D, platelet-derived growth factor D, PoDAK, vascular endothelial growth factor, vascular endothelial growth factor D, VEGF-D

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.46 complement factor D

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Results	in table
4	Activating Compound
169	AA Sequence
8	Application
1	CAS Registry Number
14	Cloned(Commentary)
11	Crystallization (Commentary)
77827	Disease/ Diagnostics
9	Expression
21	General Information
1	General Stability
41	IC50 Value
53	Inhibitors
8	KM Value [mM]
3	Localization
1	Metals/Ions
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
189	Organism
103	PDB ID
3	pI Value
4	Posttranslational Modification
28	Protein Variants
18	Purification (Commentary)
1	Reaction
1	Reaction Type
50	Reference
77	Source Tissue
11	Specific Activity [micromol/min/mg]
2	Storage Stability
41	Substrates and Products (Substrate)
7	Subunits
49	Synonyms
8	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.4.21.46 - complement factor D

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

complement factor B

Homo sapiens

P00746

the enzyme factor D is activated by its substrate factor B through interactions outside the active site. The substrate-binding, or exosite, region displays a well defined and rigid conformation

731071

-

matriptase

Homo sapiens

-

-

754127

-

additional information

2 entries

-

additional information

Homo sapiens

-

A direct repeat element located in the proximal human vegf-D gene promoter, consisting of a consensus half-site (AGGTCA) at -125/-119 and a degenerated direct repeat half-site (ATGTTA) at -99/-94 is sufficient and necessary for vegf-D transcription. The vegf-D direct repeat element is bound and activated by the orphan receptors hepatocyte nuclear factor 4A and chicken ovalbumin upstream promoter transcription factor 1 and 2 as well as transcriptional coactivators glucocorticoid receptor interacting protein 1 and cyclic AMP-responsive element binding protein-binding protein to drive vegf-D gene transcription. Histone deacetylase inhibition by trichostatin A leads to accumulation of acetylated histones H3/H4 at the vegf-D promoter, up-regulation of vegf-D mRNA levels, and transactivation of vegf-D promoter reporter gene constructs in cancer cell lines

697096

-

additional information

Homo sapiens

-

adenovirus-mediated expression of VEGF-D is significantly higher than that of baculovirus

699302

-