3.4.21.43: classical-complement-pathway C3/C5 convertase

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For detailed information about classical-complement-pathway C3/C5 convertase, go to the full flat file.

Reaction

Selective cleavage of Arg-/-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-/- bond in complement component C5 alpha-chain to form C5a and C5b =

Synonyms

C3 convertase, C3/C5 convertase, C3b 2 Bb, C3b2Bb, C3bBb, C3bBbP, C4, C423, C4b,2a, C4b,2a,3b, C4b,C2a, C4b2a, C4b2a(C3b)n, C4b2a3b, C4b2aC3b, C4bC2a, C5 convertase, classical C3 convertase, classical C5 convertase, classical pathway C3 convertase, classical pathway C3/C5 convertase, classical pathway C5 convertase, complement C3 convertase, CP C3 convertase, CP C3/C5 convertase, CP C5 convertase, EAC1,C4b,C2a, EC 3.4.21.44, high affinity C5 convertase, soluble C3 convertase, surface-bound C3 convertase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.43 classical-complement-pathway C3/C5 convertase

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Results	in table
13	Activating Compound
385	AA Sequence
2	Application
1	CAS Registry Number
2	Cloned(Commentary)
3	Crystallization (Commentary)
36	Disease/ Diagnostics
2	Expression
8	General Information
10	General Stability
8	IC50 Value
35	Inhibitors
6	KM Value [mM]
6	Localization
12	Metals/Ions
4	Molecular Weight [Da]
30	Natural Substrates/ Products (Substrates)
41	Organism
6	PDB ID
5	pH Optimum
1	pH Stability
1	Posttranslational Modification
3	Protein Variants
8	Purification (Commentary)
2	Reaction
1	Reaction Type
41	Reference
21	Source Tissue
1	Storage Stability
48	Substrates and Products (Substrate)
5	Subunits
75	Synonyms
6	Temperature Optimum [°C]
5	Temperature Stability [°C]
6	Turnover Number [1/s]

Expression

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Expression on EC 3.4.21.43 - classical-complement-pathway C3/C5 convertase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

C3a generation and C5a generation is decreased in mice deficient in factor B

Mus musculus

-

708190

expression of classical C3 convertase (C4b2a) is decreased in case of hepatitis C viral infection

Homo sapiens

-

732760