Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hepatitis virus C | inhibition of C3 convertase activity and C3b deposition onto bacterial membrane by hepatitis C virus, impairment of both C3 convertase and Factor I activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C3 + H2O | Homo sapiens | - |
component C3b + anaphylatoxin C3a | iC3b is generated by Factor I after formation of C3b. iC3b is a proteolytically inactive form of C3b that retains the ability to opsonize microbes, but cannot participate in convertase function | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood serum | - |
Homo sapiens | - |
hepatocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C3 + H2O | - |
Homo sapiens | component C3b + anaphylatoxin C3a | - |
? | |
complement component C3 + H2O | - |
Homo sapiens | component C3b + anaphylatoxin C3a | iC3b is generated by Factor I after formation of C3b. iC3b is a proteolytically inactive form of C3b that retains the ability to opsonize microbes, but cannot participate in convertase function | ? | |
complement component C5 + H2O | activity of enzyme bound to component C3b | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C3 convertase | - |
Homo sapiens |
C5 convertase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | expression of classical C3 convertase (C4b2a) is decreased in case of hepatitis C viral infection | down |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of C3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components. Inhibition of C3 convertase activity and C3b deposition onto bacterial membrane by hepatitis C virus, impairment of both C3 convertase and Factor I activity, overview | Homo sapiens |
metabolism | further processing of enzyme reaction product C3b results in the formation of iC3b and C3f, and finally C3c and C3dg | Homo sapiens |
physiological function | modulation of the upstream proteins involved in proteolytic processing of the complement cascade prior to convertase formation is critical in promoting the function of the complement system in response to infection | Homo sapiens |