Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.43 extracted from

  • Kim, H.; Meyer, K.; Di Bisceglie, A.M.; Ray, R.
    Inhibition of C3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components (2014), PLoS ONE, 9, e101422.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
hepatitis virus C inhibition of C3 convertase activity and C3b deposition onto bacterial membrane by hepatitis C virus, impairment of both C3 convertase and Factor I activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C3 + H2O Homo sapiens
-
component C3b + anaphylatoxin C3a iC3b is generated by Factor I after formation of C3b. iC3b is a proteolytically inactive form of C3b that retains the ability to opsonize microbes, but cannot participate in convertase function ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
Homo sapiens
-
hepatocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3 + H2O
-
Homo sapiens component C3b + anaphylatoxin C3a
-
?
complement component C3 + H2O
-
Homo sapiens component C3b + anaphylatoxin C3a iC3b is generated by Factor I after formation of C3b. iC3b is a proteolytically inactive form of C3b that retains the ability to opsonize microbes, but cannot participate in convertase function ?
complement component C5 + H2O activity of enzyme bound to component C3b Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
C3 convertase
-
Homo sapiens
C5 convertase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of classical C3 convertase (C4b2a) is decreased in case of hepatitis C viral infection down

General Information

General Information Comment Organism
malfunction inhibition of C3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components. Inhibition of C3 convertase activity and C3b deposition onto bacterial membrane by hepatitis C virus, impairment of both C3 convertase and Factor I activity, overview Homo sapiens
metabolism further processing of enzyme reaction product C3b results in the formation of iC3b and C3f, and finally C3c and C3dg Homo sapiens
physiological function modulation of the upstream proteins involved in proteolytic processing of the complement cascade prior to convertase formation is critical in promoting the function of the complement system in response to infection Homo sapiens