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2.7.7.89: [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase

This is an abbreviated version!
For detailed information about [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase, go to the full flat file.

Reaction

[glutamine synthetase]-O4-(5'-adenylyl)-L-tyrosine
+
phosphate
=
[glutamine synthetase]-L-tyrosine
 +
ADP

Synonyms

adenylyl(glutamine synthetase) hydrolase, adenylyl-[glutamine-synthetase] hydrolase, EC 3.1.4.15, GlnE, hydrolase adenylyl(glutamine synthetase), [glutamate-ammonia ligase]-adenylyl-L-tyrosine phosphorylase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.89 [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase

Expression

Expression on EC 2.7.7.89 - [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
gene expression is slightly repressed under nitrogen-excess conditions, and the repression is more pronounced under excess nitrogen plus carbon-limiting conditions. Variations in the concentration of uridylyltransferase and adenylyltransferase also affect the rate of glutamine synthetase synthesis
-
gene GlnE is cotranscribed with another gene, orfXE. All three Gln regulatory genes, uridylyl-transferase (GlnD), the PII protein (GlnB), and adenyly I-transferase (gInE) are constitutively expressed at a low level, i.e. their expression is independent of the nitrogen status and the RNA polymerase sigma factor
repressor MtrR the Neisseria gonorrhoeae mtrCDE efflux pump operon directly activates expression of GlnE, the dual functional adenyltransferase/deadenylase enzyme that modifies glutamine synthetase GlnA resulting in regulation of its role in glutamine biosynthesis